Håkan Eriksson

TL;DR: The data suggest a reduction in number of dopaminergic nerve terminals, as the activity of the dopamine synthesizing enzyme DOPA-decarboxylase was lowered and a reduced content of 5-hydroxyindole acetic acid was observed in the putamen and globus pallidus.

TL;DR: MRI revealed that the manganese accumulated in the globus pallidus, putamen and caudate nucleus and there were also suggestions of gliosis/edema in the posterior limb of the internal capsule, which supports the suggestion that dopaminergic nerve endings degenerate duringManganese intoxication.

TL;DR: A sensitive method, especially suitable for clinical laboratories, for the routine determination of cholinesterase activities in whole blood is presented, based on the hydrolysis of propionylthiocholine and the spectrophotometric determination of the thiocholine produced by reaction with 4,4'-dithiodipyridine.

TL;DR: The results indicate that postsynaptic structures containing D1 receptors are sensitive while cells containing D2 receptors are either spared or compensated for by up-regulation of the number of receptors on remaining sites.

TL;DR: It is shown that the manganese present in serum after exposure toManganese oxide is bound to transferrin as trivalent manganic ion, and the transferrin receptor on SHSY5Y cells can bind and internalize a mangane‐transferrin complex as efficiently as an iron‐ transferrin complex, although a saturation of the manmanese uptake was achieved.