Hamid Salimi

TL;DR: Mechanisms of RNA virus clearance and neurotoxicity during viral encephalitis are discussed with a focus on the cytokines essential for immune and neural cell inflammatory responses and interactions.

TL;DR: The major families of emerging arboviruses that cause neurologic infections, their neuropathogenesis and host neuroimmunologic responses, and current strategies for treatment and prevention of neurologic infection they cause are reviewed.

TL;DR: Advances in understanding of the CNS invasion mechanisms of different neurotropic pathogens may enable the development of strategies to control their entry and deliver drugs to mitigate established infections.

TL;DR: The ability of astrocytes to transfer virus, without de novo viral synthesis suggests they are capable of sequestering and protecting virus and thus, they could potentially facilitate viral dissemination in the CNS.

TL;DR: It is demonstrated that Venezuelan equine encephalitis virus (VEEV) strain TC83-GFP, a GFP expressing, attenuated strain with a G3A mutation within the 5' UTR that is associated with increased sensitivity to type I interferons (IFNs), does not directly impact BBB permeability and that mononuclear and endothelial cell interactions may underlie BBB disruption during alphavirusEncephalitis.