H
Han Moshage
Researcher at University Medical Center Groningen
Publications - 176
Citations - 9370
Han Moshage is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Hepatic stellate cell & Apoptosis. The author has an hindex of 50, co-authored 161 publications receiving 8420 citations. Previous affiliations of Han Moshage include University of Texas Health Science Center at Houston & University of Groningen.
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Journal ArticleDOI
Nitrite and nitrate determinations in plasma: a critical evaluation.
TL;DR: Recovering nitrite and nitrate from plasma is near-quantitative (87%) and reproducible, and nitrite in whole blood is very rapidly oxidized to nitrate, and therefore plasma nitrite determination alone is meaningless.
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Cytokines and the hepatic acute phase response
TL;DR: The acute phase response is an orchestrated response to tissue injury, infection or inflammation, and a prominent feature of this response is the induction of acute phase proteins, which are involved in the restoration of homeostasis.
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Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver
TA Vos,Guido J. E. J. Hooiveld,H. Koning,Sarah Childs,Dirk K. F. Meijer,Han Moshage,Peter L.M. Jansen,Michael Müller +7 more
TL;DR: It is concluded that endotoxin‐induced cholestasis is caused by decreased mrp2 and spgp levels, as well as an abnormal localization of these proteins, which may confer resistance to hepatocytes against cytokine‐induced metabolic stress.
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Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro.
MW Nijsten,Peter Olinga,Ege de Vries,G.M.M. (Geny) Groothuis,Pieter Limburg,H. J. ten Duis,Han Moshage,H. J. Hoekstra,Johan Bijzet,JH Zwaveling,H. Schraffordt Koops +10 more
TL;DR: It is found that PCT displayed acute phase reactant behavior in vivo after administration of both rhTNF‐α and rhIL‐6 and may be considered an acute phase protein.
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Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways.
Marieke H. Schoemaker,Laura Conde de la Rosa,Manon Buist-Homan,TE Vrenken,Rick Havinga,Klaas Poelstra,Hidde J. Haisma,Peter L.M. Jansen,Han Moshage +8 more
TL;DR: TUDCA contributes to the protection against GCDCA‐induced mitochondria‐controlled apoptosis by activating survival pathways, but independent of competition on the cell membrane, NF‐κB activation, and transcription.