M
Michael Müller
Researcher at University of East Anglia
Publications - 352
Citations - 28925
Michael Müller is an academic researcher from University of East Anglia. The author has contributed to research in topics: Peroxisome proliferator-activated receptor & Adipose tissue. The author has an hindex of 91, co-authored 333 publications receiving 26237 citations. Previous affiliations of Michael Müller include University of Göttingen & University Medical Center Groningen.
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Journal ArticleDOI
Peroxisome proliferator-activated receptor α target genes
TL;DR: In this article, the involvement of PPARalpha in peroxisomal and mitochondrial fatty acid oxidation, microsomal fatty acid hydroxylation, lipoprotein, bile and amino acid metabolism, glucose homeostasis, biotransformation, inflammation control, hepato-carcinogenesis and other pathways, through a detailed analysis of the different known or putative PPARα target genes.
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Peroxisome Proliferator-Activated Receptor Alpha Target Genes
TL;DR: An overview of the involvement of PPARα in lipid metabolism and other pathways through a detailed analysis of the different known or putative PPAR α target genes is presented.
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Nutrigenomics: goals and strategies
Michael Müller,Sander Kersten +1 more
TL;DR: Applied wisely, nutrigenomics will allow effective dietary-intervention strategies to recover normal homeostasis and to prevent diet-related diseases.
Journal ArticleDOI
Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport
Michael Müller,C. J. L. M. Meijer,Guido J.R. Zaman,Piet Borst,R.J. Scheper,Nh Mulder,E. G. E. de Vries,Peter L.M. Jansen +7 more
TL;DR: It is demonstrated that overexpression of the MRP gene in human cancer cells increases the ATP-dependent glutathione S-conjugate carrier activity in plasma membrane vesicles isolated from these cells, suggesting that MRP can cause multidrug resistance by promoting the export of drug modification products from cells.
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The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity
Rinke Stienstra,Leo A. B. Joosten,Tim B. Koenen,Berry van Tits,Janna A. van Diepen,Sjoerd A.A. van den Berg,Patrick C.N. Rensen,Peter J. Voshol,Giamilla Fantuzzi,Anneke Hijmans,Sander Kersten,Michael Müller,Wim B. van den Berg,Nico van Rooijen,Martin Wabitsch,Bart Jan Kullberg,Jos W. M. van der Meer,Thirumala D. Kanneganti,Cees J. Tack,Mihai G. Netea +19 more
TL;DR: The inflammasome is an important regulator of adipocyte function and insulin sensitivity, and caspase-1 inhibition may represent a novel therapeutic target in clinical conditions associated with obesity and insulin resistance.