H
Hanaa Hariri
Researcher at University of Texas Southwestern Medical Center
Publications - 31
Citations - 802
Hanaa Hariri is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Lipid droplet & Endoplasmic reticulum. The author has an hindex of 11, co-authored 29 publications receiving 541 citations. Previous affiliations of Hanaa Hariri include Wayne State University & Florida State University.
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Journal ArticleDOI
Lipid droplet biogenesis is spatially coordinated at ER–vacuole contacts under nutritional stress
TL;DR: It is demonstrated that yeast ER–vacuole contact sites (NVJs) physically expand in response to metabolic stress, and serve as sites for LD production, suggesting a tight metabolic link between nutritional stress and LD biogenesis that is spatially coordinated at ER–vein contact sites.
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Cerebellar ataxia disease-associated Snx14 promotes lipid droplet growth at ER-droplet contacts.
TL;DR: It is proposed that Snx14 is a novel marker for ER–LD contacts and regulates FA-stimulated LD growth.
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Mdm1 maintains endoplasmic reticulum homeostasis by spatially regulating lipid droplet biogenesis.
Hanaa Hariri,Natalie Ortiz Speer,Jade Bowerman,Sean Rogers,Gang Fu,Evan Reetz,Sanchari Datta,J. Ryan Feathers,Rupali Ugrankar,Daniela Nicastro,W. Mike Henne +10 more
TL;DR: It is proposed that Mdm1 coordinates FA activation adjacent to the vacuole to promote LD production in response to stress, thus maintaining ER homeostasis and elevating the cellular FA level.
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Drosophila Snazarus Regulates a Lipid Droplet Population at Plasma Membrane-Droplet Contacts in Adipocytes.
Rupali Ugrankar,Jade Bowerman,Hanaa Hariri,Mintu Chandra,Kevin Chen,Marie-France Bossanyi,Sanchari Datta,Sean Rogers,Kaitlyn M. Eckert,Gonçalo Vale,Alexia Victoria,Joseph Fresquez,Jeffrey G. McDonald,Steve Jean,Brett M. Collins,W. Mike Henne +15 more
TL;DR: It is proposed that Drosophila adipocytes maintain spatially distinct LD populations and Snz is identified as a regulator of LD organization and inter-organelle crosstalk.
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A pseudoatomic model of the COPII cage obtained from cryo-electron microscopy and mass spectrometry
Alex J. Noble,Qian Zhang,Jason O’Donnell,Jason O’Donnell,Hanaa Hariri,Nilakshee Bhattacharya,Alan G. Marshall,Scott M. Stagg +7 more
TL;DR: A 12-Å structure of the human COPII cage, where the tertiary structure of Sec13 and Sec31 is clearly identifiable and the two-fold symmetry of the Sec31 dimeric region in Sec13–Sec31 is broken upon cage formation and that the resulting hinge is essential to form the proper edge geometry in COPII cages.