Showing papers by "Hanafi H. Zoorob published in 2002"
27 citations
TL;DR: In this paper, the reaction of 5-bromo-2,4-diethoxypyrimidine or 5-Bromo2,2-ethoxypyridine with a perfluoroalkyl iodide in the presence of Cu-bronze followed by acid hydrolysis of the resultant 5- perfluoralkyl derivative furnishes the respective 5-perfluoro-alkyluracil and 5-pyrimidin-2(1H)one.
Abstract: The reaction of 5-bromo-2,4-diethoxypyrimidine or 5-bromo-2-ethoxypyrimidine with a perfluoroalkyl iodide in the presence of Cu-bronze followed by acid hydrolysis of the resultant 5- perfluoroalkyl derivative furnishes the respective 5-perfluoroalkyluracil and 5- perfluoroalkylpyrimidin-2(1H)one. The treatment of the perfluoroalkyluracil with NaOH or sodium alkoxide gives the respective 5-(perfluoroacyl)- or 5-(1,1-dialkoxyperfluoroalkyl)- substituted uracil. 5-(Perfluoroalkyl)pyrimidine-2(1H)one is inert under these conditions.
4 citations
1 citations