H
Hans-Jürgen Rupprecht
Researcher at University of Mainz
Publications - 131
Citations - 11972
Hans-Jürgen Rupprecht is an academic researcher from University of Mainz. The author has contributed to research in topics: Myocardial infarction & Angioplasty. The author has an hindex of 34, co-authored 131 publications receiving 11582 citations. Previous affiliations of Hans-Jürgen Rupprecht include Beaumont Hospital.
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Journal ArticleDOI
Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study.
Shamir R. Mehta,Salim Yusuf,Ron J.G. Peters,Michel E. Bertrand,Basil S. Lewis,Madhu K. Natarajan,Klas Malmberg,Hans-Jürgen Rupprecht,Feng Zhao,Susan Chrolavicius,Ingrid Copland,Keith A.A. Fox +11 more
TL;DR: In patients with acute coronary syndrome receiving aspirin, a strategy of clopidogrel pretreatment followed by long-term therapy is beneficial in reducing major cardiovascular events, compared with placebo.
Journal ArticleDOI
Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial
Hans-Christoph Diener,Julien Bogousslavsky,Lawrence M. Brass,Claudio Cimminiello,László Csiba,Markku Kaste,Didier Leys,Jordi A. Matías-Guiu,Hans-Jürgen Rupprecht +8 more
TL;DR: Adding aspirin to clopidogrel in high-risk patients with recent ischaemic stroke or transient ischaemia attack is associated with a non-significant difference in reducing major vascular events, however, the risk of life-threatening or major bleeding is increased by the addition of aspirin.
Journal ArticleDOI
Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting : the clopidogrel aspirin stent international cooperative study (CLASSICS).
TL;DR: In this article, a 28-day regimen of either 300mg clopidogrel loading dose and 325 mg/d aspirin plus 250 mg BID ticlopidine plus aspirin was used for coronary stent placement.
Journal ArticleDOI
Early versus Delayed Invasive Intervention in Acute Coronary Syndromes
Shamir R. Mehta,Christopher B. Granger,William E. Boden,Philippe Gabriel Steg,Jean-Pierre Bassand,David P. Faxon,Rizwan Afzal,Susan Chrolavicius,Sanjit S. Jolly,Petr Widimsky,Alvaro Avezum,Hans-Jürgen Rupprecht,Jun Zhu,Jacques Col,Madhu K. Natarajan,Craig Horsman,Keith A.A. Fox,Salim Yusuf +17 more
TL;DR: Early intervention did not differ greatly from delayed intervention in preventing the primary outcome, but it did reduce the rate of the composite secondary outcome of death, myocardial infarction, or refractory ischemia and was superior to delayed Intervention in high-risk patients.
Journal ArticleDOI
Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial.
Shamir R. Mehta,Jean-François Tanguay,John W. Eikelboom,Sanjit S. Jolly,Campbell D. Joyner,Christopher B. Granger,David P. Faxon,Hans-Jürgen Rupprecht,Andrzej Budaj,Alvaro Avezum,Petr Widimsky,Philippe Gabriel Steg,Jean-Pierre Bassand,Gilles Montalescot,Carlos Macaya,Giuseppe Di Pasquale,Kari Niemelä,Andrew E. Ajani,Harvey D. White,Susan Chrolavicius,Peggy Gao,Keith A.A. Fox,Salim Yusuf +22 more
TL;DR: In patients undergoing PCI for acute coronary syndromes, a 7-day double-dose clopidogrel regimen was associated with a reduction in cardiovascular events and stent thrombosis compared with the standard dose.