Hans Lengsfeld

TL;DR: In mice triolein absorption was dose-dependently inhibited by lipstatin, whereas oleic acid was absorbed normally and other pancreatic enzymes, such as phospholipase A2 and trypsin, were not inhibited even at an inhibitor concentration of 200 microM.

TL;DR: The specific activities of HGL and HPL on meal TGs were much lower than those measured in vitro under optimized assay conditions (1300-8000), however, these low specific activities are enough for the Meal TGs to be completely lipolysed, given the amounts of H GL and H PL secreted during a meal.

TL;DR: The inhibition of digestive lipases by the antiobesity drug Orlistat along with lipolysis levels and fecal fat excretion were measured in healthy humans and found to be a powerful gastric lipase inhibitor, greatly reducing gastriclipolysis of solid and liquid meals.

TL;DR: Findings clearly differentiate the OSC inhibitor Ro 48-8.071 from simvastatin, and support the view that OSC is a distinct key component in the regulation of the cholesterol synthesis pathway.

TL;DR: These findings show that tetrahydrolipstatin prevents triglyceride hydrolysis and that plasma cholecystokinin release, gallbladder emptying, and pancreatic enzyme secretion require adequate triglyceride digestion.