Pius Hildebrand

TL;DR: Although uncertainty remains, little evidence exists to suggest that any of the investigated drugs are safe in cardiovascular terms, and Naproxen seemed least harmful.

TL;DR: It is concluded that CCK is an important mediator of meal-induced gallbladder contraction and is involved in the regulation of gastrointestinal motility in man.

TL;DR: It is demonstrated by reverse transcriptase polymerase chain reaction and enzyme-linked immunoassay that TGF-β1 is a potent inducer of IL-6 mRNA and protein in primary human lung fibroblasts and this complex was found to be a JunD homodimer, which may be essential for a majority of the biological effects induced by TGF -β1 in this cell type.

TL;DR: Intravenous loxiglumide was highly potent in antagonizing CCK8-induced pancreatic enzyme and bile acid secretion as well as pancreatic polypeptide release, suggesting that CCK is a physiological mediator of the intestinal phase of meal-stimulated pancreatic and biliary responses.

TL;DR: The JunD homodimer of the transcription factor AP‐1 is identified as an essential mediator of TGF‐β‐induced effects in lung fibroblasts and offers novel targets for future therapy of fibrotic lung disease.