H
Hans Narjes
Researcher at Boehringer Ingelheim
Publications - 3
Citations - 1034
Hans Narjes is an academic researcher from Boehringer Ingelheim. The author has contributed to research in topics: Protease inhibitor (pharmacology) & Pharmacokinetics. The author has an hindex of 3, co-authored 3 publications receiving 999 citations.
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Journal ArticleDOI
An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus.
Daniel Lamarre,Paul C. Anderson,Murray D. Bailey,Pierre L. Beaulieu,Gordon Bolger,Pierre R. Bonneau,Michael Bös,Dale R. Cameron,Mireille Cartier,Michael G. Cordingley,Anne-Marie Faucher,Nathalie Goudreau,Stephen H. Kawai,George Kukolj,Lisette Lagacé,Steven R. LaPlante,Hans Narjes,Marc-André Poupart,Jean Rancourt,Roel E. Sentjens,Roger St. George,Bruno Simoneau,Gerhard G. Steinmann,Diane Thibeault,Youla S. Tsantrizos,Steven M. Weldon,Chan-Loi Yong,Montse Llinas-Brunet +27 more
TL;DR: Administration of BILN 2061 to patients infected with HCV genotype 1 for 2 days resulted in an impressive reduction of HCV RNA plasma levels, and established proof-of-concept in humans for an HCV NS3 protease inhibitor, illustrating the potential of the viral-enzyme-targeted drug discovery approach for the development of new HCV therapeutics.
Journal ArticleDOI
Afatinib pharmacokinetics and metabolism after oral administration to healthy male volunteers
Peter Stopfer,Kristell Marzin,Hans Narjes,Dietmar Gansser,Mehdi Shahidi,Martina Uttereuther-Fischer,Thomas Ebner +6 more
TL;DR: Afatinib displayed a complete mass balance with the main route of excretion via feces, and was well tolerated, indicating a high tissue distribution.
Journal ArticleDOI
corrigendum: An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
Daniel Lamarre,Paul C. Anderson,Murray D. Bailey,Pierre L. Beaulieu,Gordon Bolger,Pierre R. Bonneau,Michael Bös,Dale R. Cameron,Mireille Cartier,Michael G. Cordingley,Anne-Marie Faucher,Nathalie Goudreau,Stephen H. Kawai,George Kukolj,Lisette Lagacé,Steven R. LaPlante,Hans Narjes,Marc-André Poupart,Rancourt Jean,Roel E. Sentjens,Roger St. George,Bruno Simoneau,Gerhard G. Steinmann,Diane Thibeault,Youla S. Tsantrizos,Steven M. Weldon,Chan-Loi Yong,Montse Llinas-Brunet +27 more
TL;DR: This corrects the article to show that the Higgs boson bacterium is a prokaryotic substance, not a “spatially aggregating substance”, which is a type of “plasm” found in the fossil record.