Roger St. George

TL;DR: Administration of BILN 2061 to patients infected with HCV genotype 1 for 2 days resulted in an impressive reduction of HCV RNA plasma levels, and established proof-of-concept in humans for an HCV NS3 protease inhibitor, illustrating the potential of the viral-enzyme-targeted drug discovery approach for the development of new HCV therapeutics.

TL;DR: The studies suggest that HepatoPac is a promising in vitro model to predict in vivo liver enrichment and metabolism, especially for glucuronidation, and has demonstrated superiority over suspended hepatocytes.

TL;DR: This corrects the article to show that the Higgs boson bacterium is a prokaryotic substance, not a “spatially aggregating substance”, which is a type of “plasm” found in the fossil record.

TL;DR: Faldaprevir is predominantly excreted in feces with negligible urinary excretion, and the terminal half-life of radioactivity in plasma was approximately 23 h with no evidence of any long-lasting metabolites.

TL;DR: Radioactivity was rapidly distributed into tissues after the oral dose with peak concentrations of radioactivity in most tissues at 6 h post-dose, and the highest levels ofRadioactivity were observed in liver, lung, kidney, small intestine and adrenal gland.