Hansgeorg Schindler

TL;DR: It is indicated that this methodology has promise for characterizing rate constants and kinetics of molecular recognition complexes and for molecular mapping of biosurfaces such as membranes.

TL;DR: Both the liquid‐ordered phase characteristics and the sizes of domains match properties of membrane fractions described as detergent‐resistant membranes (DRMs), strongly suggesting that the domains seen are the in vivo correlate of DRMs and thus may be identified as lipid rafts.

TL;DR: Ceramide, a constituent of atherogenic lipoproteins, binds to CD14 and induces clustering of CD14 to co‐receptors in rafts and induces co‐clustering with Toll‐like receptor 4, Fcγ‐RIIIa (CD16a) and the tetraspanin CD81 while CD47 was dissociated.

TL;DR: Important insights are revealed regarding channel regulation of the ryanodine receptor: 1) the calcium release channel must be phosphorylated to be in the active state at conditions approximating physiological Mg concentrations (mM); and 2) there are multiple sites of phosphorylation on the calciumRelease channel with different functional consequences, which may be relevant to the regulation of E-C coupling.

TL;DR: The physical properties of bilayers of dipalmitoyl-3-sn-phosphatidylcholine are analyzed in terms of a statistical model proposed by Marcelja, which yields the probabilities of trans and gauche conformations and also those of more specific conformational defects like kinks or jogs.