H
Hari Manev
Researcher at University of Illinois at Chicago
Publications - 185
Citations - 8156
Hari Manev is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Melatonin & Glutamate receptor. The author has an hindex of 47, co-authored 185 publications receiving 7903 citations. Previous affiliations of Hari Manev include Allegheny General Hospital & Georgetown University.
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Delayed increase of Ca2+ influx elicited by glutamate: role in neuronal death.
TL;DR: It is suggested that the sustained activation and translocation of PKC primed by glutamate receptor stimulation may be the triggering event causing the protracted increase of neuronal Ca2+ influx, which appears to be important in causing neuronal death.
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Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex
TL;DR: Protection of glutamate neurotoxicity by gangliosides does not require their presence in the incubation medium; however, it is proportional to the amount of glycosphingolipid accumulated in the neuronal membranes.
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Melatonin protects neurons from singlet oxygen‐induced apoptosis
TL;DR: The results suggest that melatonin might counteract the cytotoxic action of singlet oxygen, which is a very reactive molecule that can be produced by living cells and may contribute to cytotoxicity.
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Antidepressants alter cell proliferation in the adult brain in vivo and in neural cultures in vitro
TL;DR: The action of antidepressants on cell proliferation (bromodeoxyuridine (BrdU) or [3H]thymidine incorporation) was studied in the adult rat hippocampus in vivo and in neural precursors (immature rat cerebellar granule cells) in vitro.
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Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats.
TL;DR: The results suggest that endogenous melatonin may play a neuroprotective role, and that melatonin deficiency might be a pathophysiological mechanism in neurodegenerative diseases.