H
Harminder D. Singh
Researcher at Torrey Pines Institute for Molecular Studies
Publications - 7
Citations - 454
Harminder D. Singh is an academic researcher from Torrey Pines Institute for Molecular Studies. The author has contributed to research in topics: Reductase & Multidrug tolerance. The author has an hindex of 6, co-authored 7 publications receiving 408 citations. Previous affiliations of Harminder D. Singh include University of Central Florida.
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Journal ArticleDOI
Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice
Dheeraj Verma,Babak Moghimi,Paul A. LoDuca,Harminder D. Singh,Brad E. Hoffman,Roland W. Herzog,Henry Daniell +6 more
TL;DR: This prophylactic protocol using a murine hemophilia B model was effective over a range of oral antigen doses, and controlled inhibitor formation and anaphylaxis long-term, up to 7 months (∼40% life span of this mouse strain).
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Expression of HIV-Tat protein is associated with learning and memory deficits in the mouse.
Amanda N. Carey,Elizabeth I. Sypek,Harminder D. Singh,Marc J. Kaufman,Jay P. McLaughlin,Jay P. McLaughlin +5 more
TL;DR: Evidence is provided that Tat protein expression is sufficient to mediate cognitive abnormalities seen in HIV-infected individuals and the genetically engineered GT-tg mouse may be useful for improving the understanding of the neurological underpinnings of neuroAIDS-related behaviors.
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Anxiety-like behavior of mice produced by conditional central expression of the HIV-1 regulatory protein, Tat
TL;DR: Among GT-tg mice, doxycycline significantly increased anxiety-like behavior in all tasks, commensurate with enhanced Western blot labeling of Tat1-86 protein in brain, displaying optimal effects with the 7-day regimen.
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Exposure to HIV-1 Tat in brain impairs sensorimotor gating and activates microglia in limbic and extralimbic brain regions of male mice.
TL;DR: Exposure to HIV-1 Tat protein induced sensorimotor deficits associated with acute and persistent neuroinflammation in limbic/extralimbic brain regions and increased frontal cortex GFAP.
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Wax ester synthesis is required for Mycobacterium tuberculosis to enter in vitro dormancy.
Tatiana Sirakova,Chirajyoti Deb,Jaiyanth Daniel,Harminder D. Singh,Hedia Maamar,Vinod S. Dubey,Pappachan E. Kolattukudy +6 more
TL;DR: The results indicate that the fcr1 and fcr2 gene products are involved in THE AUTHORS synthesis under in vitro dormancy-inducing conditions and that THEY play a critical role in reaching a dormant state in mycobacterial dormancy.