H
Harold G. Freund
Researcher at Roswell Park Cancer Institute
Publications - 53
Citations - 1134
Harold G. Freund is an academic researcher from Roswell Park Cancer Institute. The author has contributed to research in topics: Electron paramagnetic resonance & Hyperfine structure. The author has an hindex of 21, co-authored 53 publications receiving 1122 citations.
Papers
More filters
Journal ArticleDOI
A Novel Double Lesion in X-Irradiated DNA Consists of a Strand Break and a Base Modification
TL;DR: The present study shows that double lesions may sometimes consist of a base lesion and an associated strand break and the mechanism for the formation of double lesions is discussed.
Journal ArticleDOI
Characterization of the products of dinucleoside monophosphates d(GpN) irradiated in aqueous solutions.
TL;DR: The most interesting product is one bearing two base damages, 8-hydroxylation of the guanine base and degradation of the pyrimidine base to a formamido remnant, observed in both the intact modified dinucleoside monophosphates.
Journal ArticleDOI
Assessment of DNA damage at the dimer level: measurement of the formamide lesion.
Kellee F. Greene,Edwin E. Budzinski,Herbert Iijima,Jean B. Dawidzik,Han-Chun DeFedericis,Helen B. Patrzyc,Marianne S. Evans,Douglas T. Bailey,Harold G. Freund,Harold C. Box +9 more
TL;DR: Both UVC radiation and tirapazamine produce markedly different profiles of DNA damage, reflecting their respective mechanisms of action, but only the former produced a measurable amount of the 8-oxo-7,8-dihydroguanine lesion.
Journal ArticleDOI
Paramagnetic Resonance Spectrum of Irradiated Glycylglycine HCl
TL;DR: Electron spin resonance measurements on irradiated single crystals of glycylglycine hydrochloride show that the free radical ClNH3–CH2–CONH–CH–COOH is formed and the ESR spectrum correlates well with the structure of the undamaged crystal.
Journal ArticleDOI
Electrons trapped in single crystals of sucrose: Induced spin densities
TL;DR: In this article, the coupling tensors for the hyperfine couplings between the electron and surrounding protons have been deduced from electron nuclear double resonance (ENDOR) data.