H
Harriet S. Tenenhouse
Researcher at Montreal Children's Hospital
Publications - 102
Citations - 6774
Harriet S. Tenenhouse is an academic researcher from Montreal Children's Hospital. The author has contributed to research in topics: Hypophosphatemia & Kidney. The author has an hindex of 45, co-authored 102 publications receiving 6545 citations. Previous affiliations of Harriet S. Tenenhouse include University of California, San Francisco & University of Eastern Finland.
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Journal ArticleDOI
Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities
Laurent Beck,Andrew C. Karaplis,Norio Amizuka,Hewson As,Hidehiro Ozawa,Harriet S. Tenenhouse +5 more
TL;DR: It is demonstrated that Npt2 is a major regulator of Pi homeostasis and necessary for normal skeletal development and its relationship to autosomal disorders of renal Pi reabsorption in humans is clarified.
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Transgenic Mice Expressing Fibroblast Growth Factor 23 under the Control of the α1(I) Collagen Promoter Exhibit Growth Retardation, Osteomalacia, and Disturbed Phosphate Homeostasis
Tobias E. Larsson,Richard Marsell,Ernestina Schipani,Claes Ohlsson,Östen Ljunggren,Harriet S. Tenenhouse,Harald Jüppner,Kenneth B. Jonsson +7 more
TL;DR: The data indicate that FGF-23 induces phenotypic changes in mice resembling those of patients with ADHR, OOM, and XLH and that F GF-23 is an important determinant of Pi homeostasis and bone mineralization.
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SLC34A3 Mutations in Patients with Hereditary Hypophosphatemic Rickets with Hypercalciuria Predict a Key Role for the Sodium-Phosphate Cotransporter NaPi-IIc in Maintaining Phosphate Homeostasis
Clemens Bergwitz,Nicole M. Roslin,Martin Tieder,J C. Loredo-Osti,Murat Bastepe,Hilal Abu-Zahra,Danielle Frappier,Kelly M. Burkett,Thomas O. Carpenter,Donald Anderson,Michele Garabedian,Isabelle Sermet,T. Mary Fujiwara,T. Mary Fujiwara,Kenneth Morgan,Kenneth Morgan,Harriet S. Tenenhouse,Harriet S. Tenenhouse,Harald Jüppner +18 more
TL;DR: It is concluded that NaP(i)-IIc has a key role in the regulation of phosphate homeostasis and in individuals affected by HHRH, which is caused by SLC34A3 mutations affecting both alleles.
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Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice.
Farzana Perwad,Nasreen Azam,Martin Y. H. Zhang,Takeyoshi Yamashita,Harriet S. Tenenhouse,Anthony A. Portale +5 more
TL;DR: It is demonstrated that dietary Pi regulates the serum FGF-23 concentration in mice, and such regulation is independent of phex function.
Journal ArticleDOI
Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1α-hydroxylase expression in vitro
TL;DR: Novel findings provide evidence that FGF-23 directly regulates renal 1alpha-hydroxylase gene expression via activation of the ERK1/2 signaling pathway.