H
Harvey J. Motulsky
Researcher at University of California, San Diego
Publications - 66
Citations - 5055
Harvey J. Motulsky is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Receptor & Adrenergic receptor. The author has an hindex of 34, co-authored 65 publications receiving 4895 citations.
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Fitting curves to data using nonlinear regression: a practical and nonmathematical review.
TL;DR: This article reviews the use of nonlinear regression in a practical and nonmathematical manner to demystify non linear regression so that both its power and its limitations will be appreciated.
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Adrenergic Receptors in Man
Harvey J. Motulsky,Paul A. Insel +1 more
TL;DR: A large number of studies have shown that norepinephrine acts primarily as a neurotransmitter released from sympathetic-nerve regions of the nervous system and epinephrine acts as a “feel-good” hormone.
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Calculating receptor number from binding experiments using same compound as radioligand and competitor.
TL;DR: A simple method for calculating receptor number and affinity from competitive binding data is presented, useful when a single class of binding site is present, but is often not able to detect the presence of two classes of site.
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Externalization of beta-adrenergic receptors promoted by myocardial ischemia.
TL;DR: During myocardial ischemia, beta-adrenergic receptors were redistributed from the intracellular vesicles to the sarcolemmal fraction, where isoproterenol-stimulated adenylate cyclase activity was increased.
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Interaction of verapamil and other calcium channel blockers with alpha 1- and alpha 2-adrenergic receptors.
TL;DR: The interaction of verapamil with alpha-adrenergic receptors is not receptor subtype or tissue specific, that interaction withAlpha 1- and alpha 2- adrenergic receptor interaction is not a property of all calcium channel blockers, and that the interaction of VerapamIL withalpha-adRenergic receptors and its interaction with calcium channels occur at at least two distinct sites.