H
Hazel X. Y. Koh
Researcher at Novartis Institute for Tropical Diseases
Publications - 3
Citations - 366
Hazel X. Y. Koh is an academic researcher from Novartis Institute for Tropical Diseases. The author has contributed to research in topics: Kinetochore & Centromere. The author has an hindex of 3, co-authored 3 publications receiving 268 citations.
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Journal ArticleDOI
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
Shilpi Khare,Advait Nagle,Agnes Biggart,Yin H. Lai,Fang Liang,Lauren C. Davis,S. Whitney Barnes,Casey J. N. Mathison,Elmarie Myburgh,Elmarie Myburgh,Mu-Yun Gao,J. Robert Gillespie,Xianzhong Liu,Jocelyn Tan,Monique Stinson,Ianne C. Rivera,Jaime Ballard,Vince Yeh,Todd Groessl,Glenn C. Federe,Hazel X. Y. Koh,John D. Venable,Badry Bursulaya,Michael Shapiro,Pranab Mishra,Glen Spraggon,Ansgar Brock,Jeremy C. Mottram,Jeremy C. Mottram,Frederick S. Buckner,Srinivasa P. S. Rao,Ben G. Wen,John R. Walker,Tove Tuntland,Valentina Molteni,Richard Glynne,Frantisek Supek +36 more
TL;DR: A selective inhibitor of the kinetoplastid proteasome (GNF6702) with unprecedented in vivo efficacy, which cleared parasites from mice in all three models of infection, underscores the possibility of developing a single class of drugs for these neglected diseases.
Journal ArticleDOI
Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors.
Manuel Saldivia,Manuel Saldivia,Eric Fang,Xiaolei Ma,Elmarie Myburgh,Juliana B.T. Carnielli,Christopher Bower-Lepts,Elaine Brown,Ryan Ritchie,Suresh B Lakhsminarayana,Yen Liang Chen,Debjani Patra,Elizabeth Ornelas,Hazel X. Y. Koh,Sarah Williams,Frantisek Supek,Daniel Paape,Richard McCulloch,Marcel Kaiser,Marcel Kaiser,Michael P. Barrett,Jan Jiricek,Thierry T. Diagana,Jeremy C. Mottram,Srinivasa P. S. Rao +24 more
TL;DR: The identification and characterization of the amidobenzimidazoles (AB) protein kinase inhibitors that show nanomolar potency against T. brucei bloodstream forms and a new chemical tool for investigating the function of their divergent kinetochores are reported.
Posted ContentDOI
Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors
Manuel Saldivia,Srinivasa P. S. Rao,Eric Fang,Elmarie Myburgh,Elaine Brown,Adam J. M. Wollman,Ryan Ritchie,Suresh B Lakhsminarayana,Yen Liang Chen,Debjani Patra,Hazel X. Y. Koh,Sarah Williams,Frantisek Supek,Daniel Paape,Christopher Bower-Lepts,Mark C. Leake,Richard McCulloch,Marcel Kaiser,Marcel Kaiser,Michael P. Barrett,Jan Jiricek,Thierry T. Diagana,Jeremy C. Mottram +22 more
TL;DR: It is proposed that CLK1 is part of a novel signalling cascade that controls kinetochore function via phosphorylation of the inner kinetchore protein kinase KKT2, which is a novel drug target for trypanosomatid parasitic protozoa and a new chemical tool for investigating the function of their divergentKinetochores.