S
S. Whitney Barnes
Researcher at Genomics Institute of the Novartis Research Foundation
Publications - Â 30
Citations - Â 2885
S. Whitney Barnes is an academic researcher from Genomics Institute of the Novartis Research Foundation. The author has contributed to research in topics: Mycobacterium tuberculosis & Plasmodium falciparum. The author has an hindex of 19, co-authored 26 publications receiving 2519 citations. Previous affiliations of S. Whitney Barnes include Novartis.
Papers
More filters
Journal ArticleDOI
SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis
Kapil Tahlan,Regina Wilson,David B. Kastrinsky,Kriti Arora,Vinod Nair,Elizabeth R. Fischer,S. Whitney Barnes,John R. Walker,David Alland,Clifton E. Barry,Helena I. Boshoff +10 more
TL;DR: It is demonstrated that SQ109 disrupts cell wall assembly, as evidenced by macromolecular incorporation assays and ultrastructural analyses and that MmpL3 is a transporter of mycobacterial TMM.
Journal ArticleDOI
Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery
Stephan Meister,David Plouffe,Kelli Kuhen,Ghislain M. C. Bonamy,Tao Wu,S. Whitney Barnes,Selina Bopp,Rachel Borboa,A. Taylor Bright,A. Taylor Bright,Jianwei Che,Steve Cohen,Neekesh V. Dharia,Kerstin Gagaring,Montip Gettayacamin,Perry Gordon,Todd Groessl,Nobutaka Kato,Marcus C. S. Lee,Case W. McNamara,David A. Fidock,Advait Nagle,Tae-gyu Nam,Wendy Richmond,Jason Roland,Matthias Rottmann,Matthias Rottmann,Bin Zhou,Patrick Froissard,Patrick Froissard,Richard Glynne,Dominique Mazier,Dominique Mazier,Jetsumon Sattabongkot,Peter G. Schultz,Tove Tuntland,John R. Walker,Yingyao Zhou,Arnab K. Chatterjee,Thierry T. Diagana,Elizabeth A. Winzeler,Elizabeth A. Winzeler +41 more
TL;DR: An imidazolopiperazine scaffold series was identified that was highly enriched among compounds active against Plasmodium liver stages and shows potent in vivo blood-stage therapeutic activity.
Journal ArticleDOI
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
Shilpi Khare,Advait Nagle,Agnes Biggart,Yin H. Lai,Fang Liang,Lauren C. Davis,S. Whitney Barnes,Casey J. N. Mathison,Elmarie Myburgh,Elmarie Myburgh,Mu-Yun Gao,J. Robert Gillespie,Xianzhong Liu,Jocelyn Tan,Monique Stinson,Ianne C. Rivera,Jaime Ballard,Vince Yeh,Todd Groessl,Glenn C. Federe,Hazel X. Y. Koh,John D. Venable,Badry Bursulaya,Michael Shapiro,Pranab Mishra,Glen Spraggon,Ansgar Brock,Jeremy C. Mottram,Jeremy C. Mottram,Frederick S. Buckner,Srinivasa P. S. Rao,Ben G. Wen,John R. Walker,Tove Tuntland,Valentina Molteni,Richard Glynne,Frantisek Supek +36 more
TL;DR: A selective inhibitor of the kinetoplastid proteasome (GNF6702) with unprecedented in vivo efficacy, which cleared parasites from mice in all three models of infection, underscores the possibility of developing a single class of drugs for these neglected diseases.
Journal ArticleDOI
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy
Kevin Pethe,Patricia C. Sequeira,Sanjay Agarwalla,Kyu Y. Rhee,Kelli Kuhen,Wai Yee Phong,Viral Patel,David Beer,John R. Walker,Jeyaraj Duraiswamy,Jan Jiricek,Thomas H. Keller,Arnab K. Chatterjee,Mai Ping Tan,Mai Ping Tan,Manjunatha Ujjini,Srinivasa P. S. Rao,Luis R. Camacho,Pablo Bifani,Puiying A. Mak,Ida Ma,S. Whitney Barnes,Zhong Chen,David Plouffe,Pamela Thayalan,Seow Hwee Ng,Melvin Au,Boon Heng Lee,Bee Huat Tan,Sindhu Ravindran,Mahesh Nanjundappa,Xiuhua Lin,Anne Goh,Suresh B. Lakshminarayana,Carolyn Shoen,Michael H. Cynamon,Barry N. Kreiswirth,VĂ©ronique Dartois,Eric C. Peters,Richard Glynne,Sydney Brenner,Thomas Dick +41 more
TL;DR: It is shown that inappropriate carbon-source selection can lead to the identification of compounds devoid of efficacy in vivo, underlining the importance of developing predictive in vitro screens and the need for understanding central bacterial metabolism in vivo.
Journal ArticleDOI
Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse
Tim Wiltshire,Mathew T. Pletcher,Serge Batalov,S. Whitney Barnes,Lisa M. Tarantino,Michael P. Cooke,Hua Wu,Kevin J. Smylie,Andrey Santrosyan,Neal G. Copeland,Nancy A. Jenkins,Francis Kalush,Richard J. Mural,Richard Glynne,Steve A. Kay,Mark Raymond Adams,Colin F. Fletcher,Colin F. Fletcher +17 more
TL;DR: This work examines the arrangement (haplotype) of single-nucleotide polymorphisms across the genomes of eight inbred strains of mice to gain insight into the genetic and evolutionary factors influencing such biological variation.