Ben G. Wen

TL;DR: A selective inhibitor of the kinetoplastid proteasome (GNF6702) with unprecedented in vivo efficacy, which cleared parasites from mice in all three models of infection, underscores the possibility of developing a single class of drugs for these neglected diseases.

TL;DR: A nonsense mutation in the inositol (1,4,5) trisphosphate 3 kinase B (Itpkb) gene is revealed in Ms. T-less mice, suggesting a role for Itpkb in linking T cell receptor signaling to efficient and sustained Erk activation.

TL;DR: It is shown that site-specific incorporation of an immunogenic unnatural amino acid into a protein of interest produces high-titer antibodies that cross-react with WT protein, providing a general method for inducing an antibody response to specific epitopes of self- and foreign antigens that lead to a neutralizing immune response.

TL;DR: The nature and durability of the polyclonal IgG antibody response is characterized and the generality of p-nitrophenylalanine (pNO2Phe)-induced loss of self-tolerance is established to generate effective immunotherapeutics against cancer-associated or other weakly immunogenic antigens.

TL;DR: Evidence is provided for an alternative approach in which inhibition of the negative regulatory inositol kinase Itpkb in mature T lymphocytes results in enhanced intracellular calcium levels following antigen receptor activation leading to T cell death.