H
Heather Czapla
Researcher at Yale University
Publications - 5
Citations - 725
Heather Czapla is an academic researcher from Yale University. The author has contributed to research in topics: Endocytic cycle & Endocytosis. The author has an hindex of 4, co-authored 5 publications receiving 592 citations. Previous affiliations of Heather Czapla include Howard Hughes Medical Institute.
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Journal ArticleDOI
PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER–plasma membrane contacts
Jeeyun Chung,Federico Torta,Kaori Masai,Louise Lucast,Heather Czapla,Lukas B. Tanner,Pradeep Narayanaswamy,Markus R. Wenk,Fubito Nakatsu,Pietro De Camilli +9 more
TL;DR: Two similar ER integral membrane proteins, oxysterol-binding protein (OSBP)–related protein 5 (ORP5) and ORP8, tethered the ER to the plasma membrane (PM) via the interaction of their pleckstrin homology domains with phosphatidylinositol 4-phosphate (PI4P) in this membrane.
Journal ArticleDOI
Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits
Mirko Messa,Rubén Fernández-Busnadiego,Elizabeth Wen Sun,Hong Chen,Heather Czapla,Kristie Wrasman,Yumei Wu,Genevieve Ko,Theodora S. Ross,Beverly Wendland,Pietro De Camilli +10 more
TL;DR: It is shown that a key evolutionary conserved function of epsin, in addition to other roles that include, as it is shown here, a low affinity interaction with SNAREs, is to help generate the force that leads to invagination and then fission of clathrin-coated pits.
Journal ArticleDOI
A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells
Ramiro Nandez,Daniel M. Balkin,Mirko Messa,Liang Liang,Summer Paradise,Heather Czapla,Marco Y. Hein,James S. Duncan,Matthias Mann,Pietro De Camilli +9 more
TL;DR: It is shown that OCRL loss in Lowe syndrome patient fibroblasts impacts clathrin-mediated endocytosis and results in an endocytic defect, and that defects in clathin- mediated endocyTosis likely contribute to pathology in patients with OCRL mutations.
Journal ArticleDOI
Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway
Fubito Nakatsu,Mirko Messa,Ramiro Nandez,Heather Czapla,Yixiao Zou,Stephen M. Strittmatter,Pietro De Camilli +6 more
TL;DR: It is suggested that Sac2/INPP5F and OCRL may cooperate in the sequential dephosphorylation of PI(4,5)P2 in a partnership that mimics that of the two phosphatase modules of synaptojanin.
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