Heather M. Dann

TL;DR: Feed restriction and ketosis resulted in previously unrecognized alterations in gene network expression underlying key cellular functions and discrete metabolic events that might help explain well-documented physiological adaptations to reduced feed intake in early postpartum cows and, thus, provide molecular targets that might be useful in prevention and treatment of liver lipidosis andketosis.

TL;DR: The effects of far-off and close-up treatments on postpartum variables diminished as lactation progressed, and overfeeding during the far- off period had a greater negative impact on peripartum metabolism than did differences inClose-up period nutrition.

TL;DR: New techniques such as functional genomics, using cDNA or oligonucleotide microarrays, as well as proteomics and metabolomics, provide additional highthroughput tools to determine the effects of nutrition, management, or stressors on tissue function in development of disease.

TL;DR: A model for integrating gene expression, metabolite, and Liver composition data to explain physiological events in placenta, adipose, and liver during the periparturient period is proposed and results provide evidence that hepatic inflammatory responses occurring near parturition initiate or augment adipose catabolism.

TL;DR: Nutrient intake during the dry period had more pronounced effects on peripartal lipid metabolism and DMI than did composition of the prepartum diet.