Massimo Bionaz

TL;DR: Results challenge the proposal that SREBF1 is central for milk fat synthesis regulation and highlight a pivotal role for a concerted action among PPARG, PPARGC1A, and INSIG1.

TL;DR: Overall data suggest that any effort to avoid the acute phase response in the transition period would be useful for optimizing the productive and reproductive performance of high-yielding dairy cows.

TL;DR: A reduction in the ability of the liver to cope with the increased metabolic demand near parturition in dairy cows can be diagnosed using changes in baseline plasma PON.

TL;DR: Feed restriction and ketosis resulted in previously unrecognized alterations in gene network expression underlying key cellular functions and discrete metabolic events that might help explain well-documented physiological adaptations to reduced feed intake in early postpartum cows and, thus, provide molecular targets that might be useful in prevention and treatment of liver lipidosis andketosis.

TL;DR: The effects of far-off and close-up treatments on postpartum variables diminished as lactation progressed, and overfeeding during the far- off period had a greater negative impact on peripartum metabolism than did differences inClose-up period nutrition.