H
Hector Carrero
Researcher at National Institutes of Health
Publications - 1
Citations - 655
Hector Carrero is an academic researcher from National Institutes of Health. The author has contributed to research in topics: NALP3 & PAPA syndrome. The author has an hindex of 1, co-authored 1 publications receiving 612 citations.
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De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases.
Ivona Aksentijevich,Miroslawa Nowak,Mustapha Mallah,Jae Jin Chae,Wendy T. Watford,Sigrun R. Hofmann,Leonard D. Stein,Ricardo Russo,Donald P. Goldsmith,Peter B. Dent,Helene F. Rosenberg,Frances Austin,Elaine F. Remmers,James E. Balow,Sergio D. Rosenzweig,Hirsh D. Komarow,Nitza G. Shoham,Geryl Wood,Janet Jones,Nadira Mangra,Hector Carrero,Barbara S. Adams,Terry L. Moore,Kenneth N. Schikler,Hal M. Hoffman,Daniel J. Lovell,Robert N. Lipnick,Karyl S. Barron,John J. O'Shea,Daniel L. Kastner,Raphaela Goldbach-Mansky +30 more
TL;DR: IL-1 regulation byCIAS1 suggests that IL-1 receptor blockade may constitute a rational approach to the treatment of NOMID/CINCA syndrome, and the total number of known germline mutations in CIAS1 is increased to 20, causing a spectrum of diseases ranging from familial cold autoinflammatory syndrome to Muckle-Wells syndrome.