H
Helene F. Rosenberg
Researcher at National Institutes of Health
Publications - 239
Citations - 13857
Helene F. Rosenberg is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Virus & RNase P. The author has an hindex of 58, co-authored 239 publications receiving 12846 citations. Previous affiliations of Helene F. Rosenberg include Science Applications International Corporation.
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Journal ArticleDOI
Eosinophils: Biological Properties and Role in Health and Disease
Simon P. Hogan,Helene F. Rosenberg,Redwan Moqbel,Simon Phipps,Paul S. Foster,Paige Lacy,A. Barry Kay,Marc E. Rothenberg +7 more
TL;DR: The biology of eosinophils is summarized, focusing on transcriptional regulation of eOSinophil differentiation, characterization of the growing properties of eOsinophIL granule proteins, surface proteins and pleiotropic mediators, and molecular mechanisms of Eosinophile degranulation.
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Positive Darwinian selection after gene duplication in primate ribonuclease genes
TL;DR: In this paper, it was shown that the rate of nonsynonymous nucleotide substitution was significantly higher than that of synonymous substitution for the eosinophil cationic protein (ECP) gene, which strongly suggests that positive Darwinian selection operated in the early stage of evolution of the ECP gene.
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Eosinophils: changing perspectives in health and disease
TL;DR: New insights into the molecular pathways that control the development, trafficking and degranulation of eosinophils have improved the understanding of the immunomodulatory functions of these cells and their roles in promoting homeostasis.
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De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases.
Ivona Aksentijevich,Miroslawa Nowak,Mustapha Mallah,Jae Jin Chae,Wendy T. Watford,Sigrun R. Hofmann,Leonard D. Stein,Ricardo Russo,Donald P. Goldsmith,Peter B. Dent,Helene F. Rosenberg,Frances Austin,Elaine F. Remmers,James E. Balow,Sergio D. Rosenzweig,Hirsh D. Komarow,Nitza G. Shoham,Geryl Wood,Janet Jones,Nadira Mangra,Hector Carrero,Barbara S. Adams,Terry L. Moore,Kenneth N. Schikler,Hal M. Hoffman,Daniel J. Lovell,Robert N. Lipnick,Karyl S. Barron,John J. O'Shea,Daniel L. Kastner,Raphaela Goldbach-Mansky +30 more
TL;DR: IL-1 regulation byCIAS1 suggests that IL-1 receptor blockade may constitute a rational approach to the treatment of NOMID/CINCA syndrome, and the total number of known germline mutations in CIAS1 is increased to 20, causing a spectrum of diseases ranging from familial cold autoinflammatory syndrome to Muckle-Wells syndrome.
Journal ArticleDOI
Eosinophil trafficking in allergy and asthma.
TL;DR: Novel rational therapies including antiselectin and antichemokine receptor modalities designed to block eosinophil development and trafficking are discussed, together with the implications of recent clinical studies that have evaluated the efficacy of humanized anti-IL-5 mAb therapy.