H
Héctor Sánchez-Iranzo
Researcher at Centro Nacional de Investigaciones Cardiovasculares
Publications - 22
Citations - 598
Héctor Sánchez-Iranzo is an academic researcher from Centro Nacional de Investigaciones Cardiovasculares. The author has contributed to research in topics: Zebrafish & Regeneration (biology). The author has an hindex of 10, co-authored 21 publications receiving 421 citations. Previous affiliations of Héctor Sánchez-Iranzo include European Bioinformatics Institute & University of Bern.
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Journal ArticleDOI
Transient fibrosis resolves via fibroblast inactivation in the regenerating zebrafish heart.
Héctor Sánchez-Iranzo,María Galardi-Castilla,Andrés Sanz-Morejón,Andrés Sanz-Morejón,Juan Manuel González-Rosa,Ricardo Costa,Ricardo Costa,Alexander Ernst,Julio Sainz de Aja,Xavier Langa,Nadia Mercader,Nadia Mercader +11 more
TL;DR: It is described that during fibrosis regression, fibroblasts are not fully eliminated but become inactivated, and limiting the fibrotic response by genetic ablation of col1a2-expressing cells impaired cardiomyocyte proliferation.
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Binary recombinase systems for high-resolution conditional mutagenesis
Mario Hermann,Patrick Stillhard,Hendrik Wildner,Davide Seruggia,Davide Seruggia,Viktor Kapp,Héctor Sánchez-Iranzo,Nadia Mercader,Lluis Montoliu,Lluis Montoliu,Hanns Ulrich Zeilhofer,Hanns Ulrich Zeilhofer,Pawel Pelczar +12 more
TL;DR: Two novel dual-promoter-driven conditional mutagenesis systems designed for greater accuracy and optimal efficiency of recombination are described, which significantly extend the utility of existing Cre-responsive alleles.
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Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration
Héctor Sánchez-Iranzo,María Galardi-Castilla,Carolina Minguillón,Andrés Sanz-Morejón,Andrés Sanz-Morejón,Juan Manuel González-Rosa,Juan Manuel González-Rosa,Anastasia Felker,Alexander Ernst,Gabriela Guzmán-Martínez,Christian Mosimann,Nadia Mercader,Nadia Mercader +12 more
TL;DR: A plasticity of embryonic precursors following tbx5a fate mapping is shown and that trabecular cardiomyocytes help to rebuild the cortical myocardium during adult heart regeneration.
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2C-Cas9: a versatile tool for clonal analysis of gene function
Vincenzo Di Donato,Flavia De Santis,Thomas O. Auer,Noé Testa,Héctor Sánchez-Iranzo,Nadia Mercader,Jean-Paul Concordet,Filippo Del Bene +7 more
TL;DR: It is shown that tissue-specific gene disruption can be achieved by driving Cas9 expression with the Gal4/UAS system, and this technique has the potential to be applied to diverse model organisms, enabling tissue- specific loss-of-function and phenotypic characterization of live and fixed tissues.
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Imaging mechanical properties of sub-micron ECM in live zebrafish using Brillouin microscopy
TL;DR: This work quantifies the mechanical properties of the extra-cellular matrix (ECM) in live zebrafish using Brillouin microscopy and finds the ECM to be ~500 nm thick, and in very good agreement with electron microscopy quantification.