H
Heide M. Wilcox
Researcher at Cephalon
Publications - 5
Citations - 1621
Heide M. Wilcox is an academic researcher from Cephalon. The author has contributed to research in topics: Nerve growth factor & Superoxide dismutase. The author has an hindex of 5, co-authored 5 publications receiving 1577 citations.
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Journal ArticleDOI
Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury.
Andrew G. Reaume,Jeffrey L. Elliott,Eric K. Hoffman,Neil W. Kowall,Neil W. Kowall,Robert J. Ferrante,Robert J. Ferrante,Donald R Siwek,Donald R Siwek,Heide M. Wilcox,Dorothy G. Flood,M. Flint Beal,Robert H. Brown,Richard W. Scott,William D. Snider +14 more
TL;DR: The creation and characterization of mice completely deficient for SOD1 indicate that Cu/Zn SOD is not necessary for normal motor neuron development and function but is required under physiologically stressful conditions following injury.
Journal ArticleDOI
Proteasome inhibition enhances the stability of mouse Cu/Zn superoxide dismutase with mutations linked to familial amyotrophic lateral sclerosis.
TL;DR: Pulse-chase analyses of lysates derived from cell lines stably expressing the Cu/Zn SOD isoforms indicate that the FALS mutant Cu/ Zn S OD proteins are turned over more rapidly than wild-type SOD.
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Chronic 1,25-dihydroxyvitamin D3-mediated induction of nerve growth factor mRNA and protein in L929 fibroblasts and in adult rat brain.
Michael S. Saporito,Ellen R. Brown,Kristin C. Hartpence,Heide M. Wilcox,Jeffry L. Vaught,Susan Carswell +5 more
TL;DR: It is suggested that L929 cells may have utility in studying underlying mechanisms of NGF induction by 1,25-dihydroxyvitamin D3, and a role for NGF inducers as potential drugs for neurodegenerative disorders is supported.
Journal ArticleDOI
Pharmacological Induction of Nerve Growth Factor mRNA in Adult Rat Brain
Michael S. Saporito,Heide M. Wilcox,Kristin C. Hartpence,Michael E. Lewis,Jeffry L. Vaught,Susan Carswell +5 more
TL;DR: Findings indicate that pharmacological induction of NGF may be a viable strategy for the treatment of neurodegenerative disorders such as Alzheimer's disease and differentiate these agents by potency and duration of action.
Journal ArticleDOI
Induction of NGF by isoproterenol, 4-methylcatechol and serum occurs by three distinct mechanisms.
TL;DR: Evidence is provided that isoproterenol, 4-methylcatechol and serum induce NGF by three separate mechanisms, and all possible combinations of these inducers resulted in additive increases in the levels of NGF and NGF mRNA.