R
Robert J. Ferrante
Researcher at Boston University
Publications - 180
Citations - 36041
Robert J. Ferrante is an academic researcher from Boston University. The author has contributed to research in topics: Huntington's disease & Huntingtin. The author has an hindex of 94, co-authored 177 publications receiving 34695 citations. Previous affiliations of Robert J. Ferrante include University of Pittsburgh & United States Department of Veterans Affairs.
Papers
More filters
Journal ArticleDOI
Neuropathological classification of Huntington's disease.
Jean-Paul Vonsattel,Richard H. Myers,Thomas J. Stevens,Robert J. Ferrante,Edward D. Bird,Edward P. Richardson +5 more
TL;DR: These studies indicate that analyses of the caudate nucleus in grade 4 would reflect mainly its astrocytic composition with a component of remote neurons projecting to the striatum, which would reflect early cellular and biochemical changes in HD.
Journal ArticleDOI
Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury.
Andrew G. Reaume,Jeffrey L. Elliott,Eric K. Hoffman,Neil W. Kowall,Neil W. Kowall,Robert J. Ferrante,Robert J. Ferrante,Donald R Siwek,Donald R Siwek,Heide M. Wilcox,Dorothy G. Flood,M. Flint Beal,Robert H. Brown,Richard W. Scott,William D. Snider +14 more
TL;DR: The creation and characterization of mice completely deficient for SOD1 indicate that Cu/Zn SOD is not necessary for normal motor neuron development and function but is required under physiologically stressful conditions following injury.
Journal ArticleDOI
Mice Deficient in Cellular Glutathione Peroxidase Show Increased Vulnerability to Malonate, 3-Nitropropionic Acid, and 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine
Péter Klivényi,Ole A. Andreassen,Robert J. Ferrante,Alpaslan Dedeoglu,Gerald Mueller,Eric Lancelot,Mikhail B. Bogdanov,Julie K. Andersen,Dongmei Jiang,M. Flint Beal,M. Flint Beal +10 more
TL;DR: The present results indicate that a knock-out of GSHPx may be adequately compensated under nonstressed conditions, but that after administration of mitochondrial toxins GSHpx plays an important role in detoxifying increases in oxygen radicals.
Journal ArticleDOI
Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice.
A. M. Clement,Minh Dang Nguyen,E. A. Roberts,E. A. Roberts,M. L. Garcia,M. L. Garcia,Séverine Boillée,Séverine Boillée,M. Rule,Andrew P. McMahon,Wilder Doucette,D. Siwek,Robert J. Ferrante,Robert H. Brown,Jean-Pierre Julien,Lawrence S.B. Goldstein,Lawrence S.B. Goldstein,Don W. Cleveland,Don W. Cleveland +18 more
TL;DR: Nonneuronal cells that do not express mutant SOD1 delay degeneration and significantly extend survival of mutant-expressing motor neurons.
Journal ArticleDOI
Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease.
Minghua Chen,Victor O. Ona,Mingwei Li,Robert J. Ferrante,Klaus Fink,Shan Zhu,Jie Bian,Lei Guo,Laurie A. Farrell,Steve M. Hersch,Wendy Hobbs,Jean-Paul Vonsattel,Jang-Ho J. Cha,Robert M. Friedlander +13 more
TL;DR: It is reported that minocycline delays disease progression, inhibits casp enzyme-1 and caspase-3 mRNA upregulation, and decreases inducible nitric oxide synthetase activity, in the R6/2 mouse model of Huntington disease.