Heike Miess

TL;DR: The role of aberrant lipid biosynthesis in cancer cell migration and invasion, and in the induction of tumour angiogenesis, is explored.

TL;DR: In this paper, the effects of loss of sterol regulatory element binding proteins (SREBPs) function in non-transformed cells were investigated, and the importance of SREBP in the coordination of lipid and protein biosynthesis, two processes that are essential for cell growth and proliferation was demonstrated.

TL;DR: Reduced fatty acid metabolism due to inhibition of β-oxidation renders renal cancer cells highly dependent on the GSH/GPX pathway to prevent lipid peroxidation and ferroptotic cell death.

TL;DR: Results demonstrate that regulation of lipid composition by SREBP is essential to maintain the balance between protein and lipid biosynthesis downstream of Akt and to prevent resultant ER-stress and cell death.

TL;DR: It is found that in ccRCC, but not in prostate adenocarcinoma, flux balance analysis could predict essential metabolic genes beyond random expectation, and five of the identified metabolic genes, AGPAT6, GALT, GCLC, GSS, and RRM2B, were predicted to be dispensable in normal cell metabolism.