H
Heinrich Sauer
Researcher at University of Giessen
Publications - 181
Citations - 10291
Heinrich Sauer is an academic researcher from University of Giessen. The author has contributed to research in topics: Embryoid body & Embryonic stem cell. The author has an hindex of 53, co-authored 181 publications receiving 9469 citations. Previous affiliations of Heinrich Sauer include University of Jena & University of Cologne.
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Journal ArticleDOI
Reactive oxygen species as intracellular messengers during cell growth and differentiation.
TL;DR: The delicate intracellular interplay between oxidizing and reducing equivalents allows ROS to function as second messengers in the control of cell proliferation and differentiation.
Journal ArticleDOI
BrainAGE in Mild Cognitive Impaired Patients: Predicting the Conversion to Alzheimer’s Disease
Christian Gaser,Katja Franke,Stefan Klöppel,Nikolaos Koutsouleris,Heinrich Sauer,Alzheimer’s Disease Neuroimaging Initiative +5 more
TL;DR: A novel magnetic resonance imaging (MRI)-based biomarker that predicts the individual progression of mild cognitive impairment to AD on the basis of pathological brain aging patterns is presented and can be exploited as a tool for screening as well as for monitoring treatment options.
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Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase.
Sven Wassmann,Ulrich Laufs,Anselm T. Bäumer,Kirsten Müller,Christian Konkol,Heinrich Sauer,Michael Böhm,Georg Nickenig +7 more
TL;DR: Cholesterol-independent down-regulation of AT1 receptor gene expression and inhibition of rac1, leading to decreased ROS production, demonstrates a novel regulatory mechanism of statins that may contribute to the beneficial effects of these drugs beyond lowering of plasma cholesterol.
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Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species
Maria Wartenberg,Frederike C. Ling,Markus Müschen,Florian Klein,Helmut Acker,Max Gassmann,Kerstin Petrat,Volker Pütz,Jürgen Hescheler,Heinrich Sauer +9 more
TL;DR: It is demonstrated that with increasing size of DU‐145 prostate multicellular tumor spheroids the pericellular oxygen pressure and the generation of reactive oxygen species decreased, whereas the α‐subunit of Hif‐1 (HIF‐1α) and P‐gp were up‐regulated.
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Embryonic stem cells utilize reactive oxygen species as transducers of mechanical strain-induced cardiovascular differentiation.
TL;DR: The data outline a role of ROS as mechanotransducing molecules in mechanical strain‐stimulated cardiovascular differentiation of ES cells, and point toward a microenvironment of elevated ROS required for signaling cascades initiating cardiovascular differentiation programs.