Hélène Buteau

TL;DR: This work establishes the prolactin receptor as a key regulator of mammalian reproduction, and provides the first total ablation model to further study the role of the prolACTin receptor and its ligands.

TL;DR: The data suggest that the Box 1 region of the PRL receptor and particularly the last proline is critical for JAK2 association and subsequent activation, and support the notion that the tyrosine kinase Jak2 is implicated in activation of downstream protein effectors such as Stat5, which are involved in transcription of PRL-responsive genes.

TL;DR: Evidence is provided that internalization of the plasma membrane PRLR does not lead to nuclear translocation of the receptor, or part of it, in most fibroblasts and epithelial cells at physiological concentrations of PRL, and co-localization experiments, PRL was internalized withoutnuclear translocation.

TL;DR: It is demonstrated that the glycosylation on the asparagyl residues of the extracellular domain of the PRLR is crucial for its cell surface localization and may affect signal transduction, depending on the cell line.

TL;DR: The results show that the human PRLR can activate both beta-lactoglobulin and beta-casein milk gene promoters and that these reporter genes can be used to evaluate the functional activity of agonists and antagonists of the humanPRLR.