H
Helene Sjögren
Researcher at Sahlgrenska University Hospital
Publications - 22
Citations - 1106
Helene Sjögren is an academic researcher from Sahlgrenska University Hospital. The author has contributed to research in topics: Fusion gene & Gene rearrangement. The author has an hindex of 13, co-authored 19 publications receiving 997 citations. Previous affiliations of Helene Sjögren include University of Gothenburg.
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Journal Article
Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.
TL;DR: It is reported that a third member of the EWS, TLS/FUS gene family, TAF2N, can replace EWS as a fusion partner to TEC in EMC.
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The genomic landscape of high hyperdiploid childhood acute lymphoblastic leukemia
Kajsa Paulsson,Henrik Lilljebjörn,Andrea Biloglav,Linda Olsson,Marianne Rissler,Anders Castor,Gisela Barbany,Linda Fogelstrand,Ann Nordgren,Helene Sjögren,Thoas Fioretos,Bertil Johansson +11 more
TL;DR: Analysis of mutations on trisomic chromosomes indicated that the chromosomal gains were early events, strengthening the notion that the high hyperdiploid pattern is the main driver event in this common pediatric malignancy.
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High‐resolution genomic profiling of adenomas and carcinomas of the salivary glands reveals amplification, rearrangement, and fusion of HMGA2
Fredrik Persson,Ywonne Andrén,Marta Winnes,Barbro Wedell,Anders Nordkvist,Gunhildur Gudnadottir,Rigmor Dahlenfors,Helene Sjögren,J Mark,Göran Stenman +9 more
TL;DR: The results identify HMGA2 and MDM2 as amplification targets in PA and Ca‐ex‐PA and suggest that amplification of 12q genes (in particularMDM2), deletions of 5q23.2‐q31.1 (MYC), and amplification of ERBB2 may be of importance for malignant transformation of benign PA.
Journal Article
Fusion of the NH2-Terminal Domain of the Basic Helix-Loop-Helix Protein TCF12 to TEC in Extraskeletal Myxoid Chondrosarcoma with Translocation t(9;15)(q22;q21)
TL;DR: It is demonstrated that the NH2-terminal transactivation domains of EWS or TAF2N are not unique in their ability to convert the TEC protein into an oncogenically active fusion protein, and that they may be replaced by a domain from a bHLH protein that presumably endows the fusion protein with similar functions.
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The Complexity of KIT Gene Mutations and Chromosome Rearrangements and Their Clinical Correlation in Gastrointestinal Stromal (Pacemaker Cell) Tumors
Johanna Andersson,Helene Sjögren,Jeanne M. Meis-Kindblom,Göran Stenman,Pierre Åman,Lars-Gunnar Kindblom +5 more
TL;DR: The role of KIT mutations and chromosomal rearrangements in the pathogenesis of GIST/GIPACTs are more complex than previously recognized.