A
Anders Castor
Researcher at Lund University
Publications - 52
Citations - 1914
Anders Castor is an academic researcher from Lund University. The author has contributed to research in topics: Transplantation & Progenitor cell. The author has an hindex of 17, co-authored 46 publications receiving 1610 citations. Previous affiliations of Anders Castor include Utrecht University.
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Journal ArticleDOI
Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia
Anders Castor,Lennart Nilsson,Ingbritt Åstrand-Grundström,Miranda Buitenhuis,Carole Ramirez,Kristina Anderson,Bodil Strömbeck,Stanislaw Garwicz,Albert N. Békássy,Kjeld Schmiegelow,Birgitte Lausen,Peter Hokland,Sören Lehmann,Gunnar Juliusson,Bertil Johansson,Sten Eirik W. Jacobsen +15 more
TL;DR: It is shown that clinically and genetically different subtypes of acute lymphoblastic leukemia (ALL) originate and transform at distinct stages of hematopoietic development.
Journal ArticleDOI
Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): a randomised, open-label, intergroup study
Andrea Biondi,Martin Schrappe,Paola De Lorenzo,Anders Castor,Giovanna Lucchini,Virginie Gandemer,Rob Pieters,Jan Stary,Gabriele Escherich,Myriam Campbell,Chi Kong Li,Ajay Vora,Maurizio Aricò,Silja Röttgers,Vaskar Saha,Maria Grazia Valsecchi +15 more
TL;DR: The results suggests that imatinib in conjunction with intensive chemotherapy is well tolerated and might be beneficial for treatment of children with Philadelphia-chromosome-positive ALL.
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Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia
Henrik Lilljebjörn,Rasmus Henningsson,Axel Hyrenius-Wittsten,Linda Olsson,Christina Orsmark-Pietras,Sofia von Palffy,Maria Askmyr,Marianne Rissler,Martin Schrappe,Gunnar Cario,Anders Castor,Cornelis J.H. Pronk,Mikael Behrendtz,Felix Mitelman,Bertil Johansson,Kajsa Paulsson,Anna Andersson,Magnus Fontes,Thoas Fioretos +18 more
TL;DR: This study delineates the fusion gene landscape in a consecutive series of 195 paediatric B-cell precursor acute lymphoblastic leukaemia (BCP ALL) and identifies a subtype characterized by an ETV6-RUNX1-like gene-expression profile and coexisting ETV 6 and IKZF1 alterations.
Journal ArticleDOI
The genomic landscape of high hyperdiploid childhood acute lymphoblastic leukemia
Kajsa Paulsson,Henrik Lilljebjörn,Andrea Biloglav,Linda Olsson,Marianne Rissler,Anders Castor,Gisela Barbany,Linda Fogelstrand,Ann Nordgren,Helene Sjögren,Thoas Fioretos,Bertil Johansson +11 more
TL;DR: Analysis of mutations on trisomic chromosomes indicated that the chromosomal gains were early events, strengthening the notion that the high hyperdiploid pattern is the main driver event in this common pediatric malignancy.
Journal ArticleDOI
High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle.
Alex J. Tipping,Cristina Pina,Anders Castor,Dengli Hong,Neil P. Rodrigues,Lorenza Lazzari,Gillian May,Sten Eirik W. Jacobsen,Sten Eirik W. Jacobsen,Tariq Enver +9 more
TL;DR: Gata-2 activity inhibits cell cycle in vitro and in vivo, highlighting GATA-2 as a molecular entry point into the transcriptional program regulating quiescence in human hematopoietic stem and progenitor cells.