T
Thoas Fioretos
Researcher at Lund University
Publications - 194
Citations - 8464
Thoas Fioretos is an academic researcher from Lund University. The author has contributed to research in topics: Myeloid leukemia & Leukemia. The author has an hindex of 47, co-authored 177 publications receiving 7418 citations. Previous affiliations of Thoas Fioretos include Katholieke Universiteit Leuven & Science for Life Laboratory.
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Journal ArticleDOI
The emerging complexity of gene fusions in cancer
TL;DR: The spectrum of gene fusions in cancer and how the methods to identify them have evolved are described, and the conceptual implications of current, sequencing-based approaches for detection are discussed.
Journal ArticleDOI
Cytogenetic and Molecular Genetic Evolution of Chronic Myeloid Leukemia
TL;DR: It is suggested that all these aberrations, occurring in >5% of CML with secondary changes, should be denoted major route abnormalities, except for slightly lower frequencies of the most common changes in the latter group.
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The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias.
Anna Andersson,Anna Andersson,Jing Ma,Jianmin Wang,Xiang Chen,Amanda Larson Gedman,Jinjun Dang,Joy Nakitandwe,Linda Holmfeldt,Matthew Parker,John Easton,Robert Huether,Richard W. Kriwacki,Michael Rusch,Gang Wu,Yongjin Li,Heather L. Mulder,Susana C. Raimondi,Stanley Pounds,Guolian Kang,Lei Shi,Jared Becksfort,Pankaj Gupta,Debbie Payne-Turner,Bhavin Vadodaria,Kristy Boggs,Donald Yergeau,Jayanthi Manne,Guangchun Song,Michael N. Edmonson,Panduka Nagahawatte,Lei Wei,C. Cheng,Deqing Pei,Rosemary Sutton,Nicola C. Venn,Albert Chetcuti,Amanda Rush,Daniel Catchpoole,Jesper Heldrup,Thoas Fioretos,Charles Lu,Li Ding,Ching-Hon Pui,Sheila A. Shurtleff,Charles G. Mullighan,Elaine R. Mardis,Richard K. Wilson,Tanja A. Gruber,Jinghui Zhang,James R. Downing +50 more
TL;DR: Infant acute lymphoblastic leukemia (ALL) with MLL rearrangements (MLL-R) represents a distinct leukemia with a poor prognosis and has one of the lowest frequencies of somatic mutations of any sequenced cancer, with the predominant leukemic clone carrying a mean of 1.3 non-silent mutations.
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Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11).
Pierre Åman,David Ron,Nils Mandahl,Thoas Fioretos,Sverre Heim,Kristina Arheden,Helena Willén,Anders Rydholm,Felix Mitelman +8 more
TL;DR: It is demonstrated that the 12q breakpoint of the t( 12;16) in MLS differs from those in the other tumors investigated, even in cases with no cytogenetically visible differences in breakpoint position, that CHOP rearrangement is specific for MLS, and that the breakpoints cluster to the 5′ region of the gene.
Journal ArticleDOI
Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13)
Ioannis Panagopoulos,Thoas Fioretos,Margareth Isaksson,Ulf Samuelsson,Rolf Billström,Bodil Strömbeck,Felix Mitelman,Bertil Johansson +7 more
TL;DR: It is shown here that a novel t(10;16)(q22;p13) in a childhood AML M5a leads to a MORF-CBP chimera, and their exact role in the leukemogenic process remains to be elucidated.