Hemendra Pratap Singh

TL;DR: In silico metabolic and toxicity study of the synthesized compounds were performed and the predicted result showed that the compound having hydroxyl functional group undergo sulfate and O-glucuronide conjugation reaction and methoxy derivatives undergo demethylation reaction.

TL;DR: In this article, a new pharmacophore "Chalconesemicarbazone" was designed by pharmacophores hybridization approach of drug design, which was synthesized and evaluated for their antioxidant activity by reducing power assay.

TL;DR: In this paper, molecular iodine was utilized in a one-pot, solid phase, solvent-free reaction between 2-aminothiophenol and benzoic acid derivatives to obtain highly economical and excellent yield of benzothiazole derivatives in comparison to polyphosphoric acid-and [pmIm]−Br•catalyzed microwave synthesis reactions.

TL;DR: MD simulation results confirm that the protein interacting with both hit molecules is stabilized in the chosen POPC lipid bilayer membrane, and can serve as the basis for designing and developing COVID-19 inhibitors.

TL;DR: Hydroalcoholic extract was more active against all bacteria, while Bougainvillea glabra ‘snow white’ was not effective against Bacillus subtilis and Micrococcus leuteus while B. glabRA ‘choicy” was noteffective against Proteus vulgaris.