H
Hemu Patel
Researcher at University Hospitals of Leicester NHS Trust
Publications - 19
Citations - 1219
Hemu Patel is an academic researcher from University Hospitals of Leicester NHS Trust. The author has contributed to research in topics: Sputum & COPD. The author has an hindex of 10, co-authored 17 publications receiving 1040 citations. Previous affiliations of Hemu Patel include University of Leicester.
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Journal ArticleDOI
Acute Exacerbations of Chronic Obstructive Pulmonary Disease: Identification of Biologic Clusters and Their Biomarkers
Mona Bafadhel,S McKenna,Sarah Terry,Vijay Mistry,C Reid,Pranabashis Haldar,M McCormick,Koirobi Haldar,Tatiana Kebadze,Annelyse Duvoix,Kerstin Lindblad,Hemu Patel,Paul Rugman,Paul Dodson,Martin Jenkins,Michael A. Saunders,Paul Newbold,Ruth H. Green,Per Venge,David A. Lomas,Michael R. Barer,Sebastian L. Johnston,Ian D. Pavord,Christopher E. Brightling +23 more
TL;DR: In this paper, the authors investigated biomarker expression in COPD exacerbations to identify biologic clusters and determine biomarkers that recognize clinical exacerbation phenotypes, namely those associated with bacteria, viruses, or eosinophilic airway inflammation.
Journal ArticleDOI
Association Between Pathogens Detected Using Quantitative Polymerase Chain Reaction With Airway Inflammation in COPD at Stable State and Exacerbations
Bethan Barker,Koirobi Haldar,Hemu Patel,Ian D. Pavord,Michael R. Barer,Christopher E. Brightling,Mona Bafadhel +6 more
TL;DR: At stable state, H influenzae is associated with increasedAirway inflammation in COPD and the relationship between bacterial load changes of specific pathogens and airway inflammation at exacerbation and recovery warrants further investigation.
Journal ArticleDOI
Airway bacteria measured by quantitative polymerase chain reaction and culture in patients with stable COPD: relationship with neutrophilic airway inflammation, exacerbation frequency, and lung function
Mona Bafadhel,Koirobi Haldar,Bethan Barker,Hemu Patel,Vijay Mistry,Michael R. Barer,Ian D. Pavord,Christopher E. Brightling +7 more
TL;DR: Persistence, whether defined by culture, qPCR, or both, was associated with a higher sputum neutrophil count, lower forced expiratory volume in 1 second (FEV1), and worsened quality of life.
Journal ArticleDOI
Phenotypically Adapted Mycobacterium tuberculosis Populations from Sputum Are Tolerant to First-Line Drugs
Obolbek Turapov,Benjamin D. O'Connor,Asel A. Sarybaeva,Caroline M. Williams,Hemu Patel,Abdullaat S. Kadyrov,Akpay Sarybaev,Gerrit Woltmann,Michael R. Barer,Michael R. Barer,Galina V. Mukamolova +10 more
TL;DR: In this paper, the authors describe protocols for the cryopreservation and direct assessment of antimicrobial tolerance of these M. tuberculosis populations within sputum, and show that first-line drugs achieved only modest bactericidal effects on all three populations over 7 days (1 to 2.5 log 10 reductions).
Acute Exacerbations of COPD: Identification of Biological Clusters and Their Biomarkers
Mona Bafadhel,S McKenna,Sarah Terry,Vijay Mistry,C Reid,Pranabashis Haldar,M McCormick,Koirobi Haldar,Tatiana Kebadze,Annelyse Duvoix,Kerstin Lindblad,Hemu Patel,Paul Rugman,P Dodson,Martin Jenkins,Michael A. Saunders,Paul Newbold,Ruth H. Green,Per Venge,David A. Lomas,Michael R. Barer,Sebastian L. Johnston,I D Pavord,C E Brightling +23 more