R
Ruth H. Green
Researcher at Glenfield Hospital
Publications - 83
Citations - 12664
Ruth H. Green is an academic researcher from Glenfield Hospital. The author has contributed to research in topics: Asthma & Sputum. The author has an hindex of 35, co-authored 83 publications receiving 11866 citations. Previous affiliations of Ruth H. Green include University Hospitals of Leicester NHS Trust.
Papers
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Journal ArticleDOI
Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma
Pranabashis Haldar,Christopher E. Brightling,Beverley Hargadon,Sunil Gupta,W Monteiro,Ana R. Sousa,Richard P. Marshall,Peter Bradding,Ruth H. Green,Andrew J. Wardlaw,Ian D. Pavord +10 more
TL;DR: The results of this study suggest that eosinophils have a role as important effector cells in the pathogenesis of severe exacerbations of asthma in this patient population.
Journal ArticleDOI
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.
Ruth H. Green,Christopher E. Brightling,S McKenna,Beverley Hargadon,Debbie Parker,Peter Bradding,Andrew J. Wardlaw,Ian D. Pavord +7 more
TL;DR: A treatment strategy directed at normalisation of the induced sputum eosinophil count reduces asthma exacerbations and admissions without the need for additional anti-inflammatory treatment.
Journal ArticleDOI
Cluster analysis and clinical asthma phenotypes.
Pranab Haldar,Ian D. Pavord,Dominic E. Shaw,Mike A. Berry,Mike Thomas,Christopher E. Brightling,Andrew J. Wardlaw,Ruth H. Green +7 more
TL;DR: Cluster analysis offers a novel multidimensional approach for identifying asthma phenotypes that exhibit differences in clinical response to treatment algorithms, and is specific to refractory asthma.
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Acute Exacerbations of Chronic Obstructive Pulmonary Disease: Identification of Biologic Clusters and Their Biomarkers
Mona Bafadhel,S McKenna,Sarah Terry,Vijay Mistry,C Reid,Pranabashis Haldar,M McCormick,Koirobi Haldar,Tatiana Kebadze,Annelyse Duvoix,Kerstin Lindblad,Hemu Patel,Paul Rugman,Paul Dodson,Martin Jenkins,Michael A. Saunders,Paul Newbold,Ruth H. Green,Per Venge,David A. Lomas,Michael R. Barer,Sebastian L. Johnston,Ian D. Pavord,Christopher E. Brightling +23 more
TL;DR: In this paper, the authors investigated biomarker expression in COPD exacerbations to identify biologic clusters and determine biomarkers that recognize clinical exacerbation phenotypes, namely those associated with bacteria, viruses, or eosinophilic airway inflammation.
Journal ArticleDOI
Evidence of a role of tumor necrosis factor alpha in refractory asthma.
Mike A. Berry,Beverley Hargadon,Maria Shelley,Debbie Parker,Dominick E. Shaw,Ruth H. Green,Peter Bradding,Christopher E. Brightling,Andrew J. Wardlaw,Ian D. Pavord +9 more
TL;DR: Patients with refractory asthma have evidence of up-regulation of the TNF-alpha axis, and treatment with etanercept was associated with a significant increase in the concentration of methacholine required to provoke a 20 percent decrease in the forced expiratory volume in one second.