Heng Sun

TL;DR: The development of tumor‐pH‐sensitive photodynamic nanoagents (PPNs) comprised of self‐assembled photosensitizers grafted pH‐responsive polymeric ligands and UCNPs demonstrates the attractive properties of both UCNP‐mediated deep‐tissue penetration of light and high therapeutic selectivity in vitro and in vivo.

TL;DR: In this article, the authors reported catalytic activity tunable ceria nanoparticles (CNPs) as context-dependent reactive oxygen species scavengers, which can prevent chemotherapy-induced acute kidney injury without interfering with chemotherapeutic agents.

TL;DR: CeNZs can effectively scavenge ROS in impaired hepatocytes for detoxification and generate abundant oxygen based on their catalase (CAT)-mimic activity, thus further alleviating hypoxia and suggesting the future clinical use of CeNZs for DILI treatment, especially for the late stage DILi treatment.

TL;DR: In this paper, a ceria nanoparticle (CeNP-) based phosphatase-mimetic nano-stabilizer with a long-term therapeutic time window is developed for allergic disease prevention.

TL;DR: The THN can bind to hyperphosphorylated and/or aggregated tau and selectively accumulate in cells undergoing tauopathy and further promotes the clearance of pathogenic tau accumulation by stimulating autophagic flux, consequently rescuing neuron viability and cognitive functions in AD rats.