Henri Monteil

TL;DR: The virulence of Staphylococcus aureus is essentially determined by cell wall associated proteins and secreted toxins that are regulated and expressed according to growth phases and/or growth conditions.

TL;DR: The cosecretion of these five proteins led to six possible synergistic combinations between F and S components, two of which had dermonecrotic activity on rabbit skin, and all six were leukocytolytic on glass-adsorbed leukocytes.

TL;DR: DNA hybridisation of 309 consecutive Staphylococcus aureus clinical isolates with oligonucleotide probes specific for genes encoding Panton-Valentine leucocidin (luk-PV) and gamma-haemolysin (hlg) revealed that 99% of randomly selected strains carried the hlg locus whereas only 2% harboured the luk-pV as well as the hLg loci.

TL;DR: LukE+LukD was as effective as the Panton‐Valentine leucocidin for inducing dermonecrosis when injected in the rabbit skin, but not hemolytic and poorlyLeucotoxic compared to other leucotoxins expressed by Staphylococcus aureus.

TL;DR: X‐ray crystallography of the α‐hemolysin pore has shown it is a mushroom‐shaped, hollow heptamer, almost entirely consisting of β‐structure, and γ‐Hemolysin pores seem to be organized as α‐ Hemolysin, but should contain an even number of each component, alternating in a 1:1 stoichiometry.