Henrik Seir Thoke

TL;DR: The results indicate that the periodicity of both glycolytic oscillations and dipolar relaxation are equally affected by D2O in a dose-dependent manner, and offer a new insight into the coupling of an emergent intensive physicochemical property of the cell and a central metabolite (ATP) produced by a robustly oscillating metabolic process.

TL;DR: This work measured temporal oscillations in thermodynamic variables such as temperature, heat flux, and cellular volume in suspensions of non-dividing yeast cells which exhibit temporal glycolytic oscillations, suggesting strong coupling between them and calls into question the notion that metabolic processes are essentially dissipative.

TL;DR: The results represent the first demonstration that the dynamic behaviour of a metabolic process can be regulated by a cell-wide physical property: the dynamic state of intracellular water, which represents an emergent property.

TL;DR: The results support the view that the extent of intracellular water dipolar relaxation is regulated by the ability of cytoplasmic proteins to polarize intrACEllular water with the assistance of ATP, as suggested in the Association-Induction (AI) hypothesis.

TL;DR: The method appears to be a general method for delivery of proteins to cells using chitosan-TPP nanoparticles as a drug delivery system, since structurally unrelated proteins such as BSA and p53 with different isoelectrical points can be encapsulated in the chito-tripolyphosphate nanoparticles and be effectively internalized by the cells.