H
Herbert C. Morse
Researcher at National Institutes of Health
Publications - 400
Citations - 23200
Herbert C. Morse is an academic researcher from National Institutes of Health. The author has contributed to research in topics: B cell & Lymphoma. The author has an hindex of 77, co-authored 400 publications receiving 21998 citations. Previous affiliations of Herbert C. Morse include University of Southampton & Istituto Superiore di Sanità.
Papers
More filters
Journal ArticleDOI
STAT6-Deficient Mice Exhibit Normal Induction of Murine AIDS and Expression of Immunoglobulin E following Infection with LP-BM5 Murine Leukemia Viruses
TL;DR: It is concluded that B cells from mice with MAIDS activate unique IL-4- and STAT6-independent signaling pathways for B-cell activation and differentiation, including immunoglobulin class switch-recombination to IgE.
Journal ArticleDOI
Oncogenic Myc translocations are independent of chromosomal location and orientation of the immunoglobulin heavy chain locus.
Elizabeth Spehalski,Alexander L. Kovalchuk,John Collins,Genqing Liang,Wendy Dubois,Herbert C. Morse,David O. Ferguson,Rafael Casellas,Wesley A. Dunnick +8 more
TL;DR: It is demonstrated that a transgene containing the Ig heavy chain constant region locus, inserted into five different chromosomal locations, can undergo translocations involving Myc and these translocations are able to generate plasmacytomas in each transgenic line.
Journal ArticleDOI
Functional deficiency in IL-7 caused by an N-ethyl-N-nitrosourea-induced point mutation.
TL;DR: In vitro treatment of B-cell progenitors from mutant mice with IL-7 induced them to differentiate into pre-BII cells, which provides a new model for studying the functions ofIL-7 on a pure C57BL/6 background.
Journal ArticleDOI
Early Generated B-1-Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma-like Neoplasia in Aged Mice.
Kyoko Hayakawa,Anthony M. Formica,Yuka Nakao,Daiju Ichikawa,Daiju Ichikawa,Susan A. Shinton,Joni Brill-Dashoff,Mitchell R. Smith,Mitchell R. Smith,Herbert C. Morse,Richard R. Hardy +10 more
TL;DR: It is revealed that early generated B cells, as an outcome of B-1 cell development, can progress to become lymphocytosis, lymphoma, and mantle cell lymphoma–like neoplasia in aged mice.
Journal ArticleDOI
Genetic control of B- and T-lymphocyte abnormalities of NZB mice in crosses with B10.D2 mice.
TL;DR: There was a common genetic influence on plasma cell frequency, IgM secretion per plasma cell and production of thymocyte-binding antibodies which was distinct from the genes governing the ability to generate a cytotoxic T lymphocyte response to H-2-compatible cells.