H
Herbert C. Morse
Researcher at National Institutes of Health
Publications - 400
Citations - 23200
Herbert C. Morse is an academic researcher from National Institutes of Health. The author has contributed to research in topics: B cell & Lymphoma. The author has an hindex of 77, co-authored 400 publications receiving 21998 citations. Previous affiliations of Herbert C. Morse include University of Southampton & Istituto Superiore di Sanità.
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IRF8 Governs Expression of Genes Involved in Innate and Adaptive Immunity in Human and Mouse Germinal Center B Cells
TL;DR: It is shown that IRF8 binds a large number of genes by targeting two distinct motifs, half of which are also targeted by PU, and contributes to multiple aspects of the biology of mature B cells including critical components of the molecular crosstalk among GC B cells, T follicular helper cells, and follicular dendritic cells.
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Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression.
Kyoko Hayakawa,Anthony M. Formica,Joni Brill-Dashoff,Susan A. Shinton,Daiju Ichikawa,Yan Zhou,Herbert C. Morse,Richard R. Hardy +7 more
TL;DR: Hayakawa et al. show that distinctive B-lineage progression from B-1 development allows for generation of B1a cells with restricted BCRs and self-renewal capacity, both contributing to potential for CLL progression.
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Global DNA methylation profiling reveals silencing of a secreted form of Epha7 in mouse and human germinal center B-cell lymphomas.
David W. Dawson,Jason S. Hong,Rhine R. Shen,Samuel W. French,Joshua J. Troke,Yue-Zhong Wu,Shih-Shih Chen,Dorina Gui,Moira Regelson,York Marahrens,Herbert C. Morse,J. Said,Christoph Plass,Michael A. Teitell +13 more
TL;DR: These data provide the first set of hypermethylated genes with the potential to complement TCL1-mediated GC B-cell transformation and spread, and identify a secreted isoform of EPHA7, a member of the Eph family of receptor tyrosine kinases that is able to influence tumor invasiveness, metastasis and neovascularization.
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Increased Brain Levels of Platelet‐Activating Factor in a Murine Acquired Immune Deficiency Syndrome Are NMDA Receptor‐Mediated
Keiji Nishida,Sanford P. Markey,Yelena Kustova,Herbert C. Morse,Phil Skolnick,Anthony S. Basile,Yoshitatsu Sei +6 more
TL;DR: Results indicate that the LP‐BM5 MuLV‐induced increases in brain PAF levels are the result of NMDA receptor activation and are consistent with the hypothesis that elevated CNSPAF levels contribute to the behavioral deficits observed in LP‐ BM5 Mu LV‐infected mice.
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SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy
John P. Didion,Ryan J. Buus,Zohreh Naghashfar,David W. Threadgill,Herbert C. Morse,Fernando Pardo-Manuel de Villena +5 more
TL;DR: The results demonstrate that SNP array profiling is an effective method to combat cell line misidentification and may have substantial implications for studies that are dependent on the expected background of their cell cultures.