H
Herbert Lazarus
Researcher at Harvard University
Publications - 55
Citations - 6697
Herbert Lazarus is an academic researcher from Harvard University. The author has contributed to research in topics: Antigen & Monoclonal antibody. The author has an hindex of 26, co-authored 55 publications receiving 6562 citations. Previous affiliations of Herbert Lazarus include University of Oxford & Boston Children's Hospital.
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Journal ArticleDOI
A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer.
Robert C. Bast,Thomas L. Klug,E St John,Eric Jenison,Jonathan M. Niloff,Herbert Lazarus,Ross S. Berkowitz,T. Leavitt,C.T. Griffiths,Leroy M. Parker,Vincent R. Zurawski,Robert C. Knapp +11 more
TL;DR: Determination of CA 125 levels may aid in monitoring the response to treatment in patients with epithelial ovarian cancer, and rising or falling levels ofCA 125 correlated with progression or regression of disease in 42 of 45 instances.
Journal ArticleDOI
Reactivity of a monoclonal antibody with human ovarian carcinoma.
TL;DR: A murine monoclonal antibody (OC125) has been developed that reacts with each of six epithelial ovarian carcinoma cell lines and with cryopreserved tumor tissue from 12 of 20 ovarian cancer patients, but does not bind to a variety of nonmalignant tissues, including adult and fetal ovary.
Journal ArticleDOI
A monoclonal antibody to human acute lymphoblastic leukaemia antigen
TL;DR: The present report describes the generation and characterisation of a monoclonal antibody specific for a common ALL antigen (CALLA) previously identified by conventional heteroantisera.
Journal ArticleDOI
A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer
Robert C. Bast,Thomas L. Klug,Elena S. St. John,Eric Jenison,Jonathan M. Niloff,Herbert Lazarus,Ross S. Berkowtiz,T. Leavitt,C. Thomas Griffiths,Leroy M. Parker,Vincent R. Zurawski,Robert C. Knapp +11 more
TL;DR: Determination of CA 125 levels may aid in monitoring the response to treatment in patients with epithelial ovarian cancer, and rising or falling levels ofCA 125 correlated with progression or regression of disease in 42 of 45 instances.
Journal Article
Two functionally distinct subpopulations of human T cells that collaborate in the generation of cytotoxic cells responsible for cell-mediated lympholysis.
TL;DR: Isolation of strongly reactive, TH2+, from weakly reactive,TH2- T cells by fluorescence-activated cell sorting revealed that the TH2+ subset contained most of the killer activity in cell-mediated lympholysis (CML), but had a diminished response in MLC and a suboptimal or negligible proliferative response to soluble antigens (mumps, PPD, tetanus toxoid).