Journal ArticleDOI
A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer.
Robert C. Bast,Thomas L. Klug,E St John,Eric Jenison,Jonathan M. Niloff,Herbert Lazarus,Ross S. Berkowitz,T. Leavitt,C.T. Griffiths,Leroy M. Parker,Vincent R. Zurawski,Robert C. Knapp +11 more
TLDR
Determination of CA 125 levels may aid in monitoring the response to treatment in patients with epithelial ovarian cancer, and rising or falling levels ofCA 125 correlated with progression or regression of disease in 42 of 45 instances.Abstract:Â
The murine monoclonal antibody OC 125 reacts with an antigen (CA 125) common to most nonmucinous epithelial ovarian carcinomas. An assay has been developed to detect CA 125 in serum. By this assay, only 1 per cent of 888 apparently healthy persons and 6 per cent of 143 patients with nonmalignant disease had serum CA 125 levels above 35 U per milliliter. In contrast, 83 of 101 patients (82 per cent) with surgically demonstrated ovarian carcinoma had elevated levels of antigen. In 38 patients with epithelial ovarian carcinoma monitored on 2 to 18 occasions during 2 to 60 months, antigen levels ranged from less than 1 to more than 8000 U per milliliter. Rising or falling levels of CA 125 correlated with progression or regression of disease in 42 of 45 instances (93 per cent). Determination of CA 125 levels may aid in monitoring the response to treatment in patients with epithelial ovarian cancer.read more
Citations
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The Human Plasma Proteome History, Character, and Diagnostic Prospects
TL;DR: This work speculates on the reasons behind this large discrepancy between the expectations arising from proteomics and the realities of clinical diagnostics and suggests approaches by which protein-disease associations may be more effectively translated into diagnostic tools in the future.
Journal ArticleDOI
Use of proteomic patterns in serum to identify ovarian cancer
Emanuel F. Petricoin,Ali M. Ardekani,Ben A. Hitt,Peter J. Levine,Vincent A. Fusaro,Seth M. Steinberg,Gordon B. Mills,Charles B. Simone,David A. Fishman,Elise C. Kohn,Lance A. Liotta +10 more
TL;DR: A bioinformatics tool was developed and used to identify proteomic patterns in serum that distinguish neoplastic from non-neoplastic disease within the ovary, justifying a prospective population-based assessment of proteomic pattern technology as a screening tool for all stages of ovarian cancer in high-risk and general populations.
Journal ArticleDOI
Cancer of the Ovary
TL;DR: The clinical features of ovarian cancer and recent advances in postoperative management are described, including bilateral salpingo-oophorectomy in selected women.
Journal ArticleDOI
The biology of ovarian cancer: new opportunities for translation
TL;DR: Increase in long-term survival in ovarian cancer patients might be achieved by translating recent insights at the molecular and cellular levels to personalize individual strategies for treatment and to optimize early detection.
Journal ArticleDOI
Mucins in cancer: function, prognosis and therapy.
TL;DR: The findings that certain transmembrane mucins induce transformation and promote tumour progression have provided the experimental basis for demonstrating that inhibitors of their function are effective as anti-tumour agents in preclinical models.
References
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A Coefficient of agreement for nominal Scales
TL;DR: In this article, the authors present a procedure for having two or more judges independently categorize a sample of units and determine the degree, significance, and significance of the units. But they do not discuss the extent to which these judgments are reproducible, i.e., reliable.
Journal ArticleDOI
Reactivity of a monoclonal antibody with human ovarian carcinoma.
TL;DR: A murine monoclonal antibody (OC125) has been developed that reacts with each of six epithelial ovarian carcinoma cell lines and with cryopreserved tumor tissue from 12 of 20 ovarian cancer patients, but does not bind to a variety of nonmalignant tissues, including adult and fetal ovary.
Journal ArticleDOI
Immunopathologic characterization of a monoclonal antibody that recognizes common surface antigens of human ovarian tumors of serous, endometrioid, and clear cell types.
TL;DR: OC125 recognizes a common antigen in some but not all ovarian tumors of serous, clear cell, endometrioid, or undifferentiated type, and may prove useful in the pathologic and cytologic identification of certain types of ovarian tumor cells.
Journal ArticleDOI
Multiple biochemical markers in patients with gynecologic malignancies.
Elvis S. Donaldson,J.R. van Nagell,S. Pursell,William R. Meeker,Rafiah Kashmiri,J. van Devoorde +5 more
TL;DR: Effective plasma and tumor antigen screening during initial evaluation of patients with gynecologic tumors should help to identify the most appropriate antigen for immunodetection procedures and for serial plasma determinations following therapy.
Journal ArticleDOI
Peritoneoscopy: A Valuable Staging Tool in Ovarian Carcinoma
Stephen H. Rosenoff,Robert C. Young,Tom Anderson,Charles M. Bagley,Bruce A. Chabner,Philip S. Schein,Susan P. Hubbard,Vincent T. DeVita +7 more
TL;DR: "Second look" peritoneoscopy precluded the need the laparotomy in 5 to 13 patients achieving as apparent clinical remission, and the routine shielding if the liver area ordinarily used with total abdominal radiotherapy would select these patients for therapeutic failure.