Herman G.M. Westenberg

TL;DR: In this paper, the authors evaluated the effect of bilateral deep brain stimulation of the nucleus accumbens on treatment-resistant treatment of treatment-refractory OCD using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS).

TL;DR: Testing whether alpha-lactalbumin, a whey protein with a high tryptophan content, may increase the plasma Trp-LNAA ratio and reduce depressive mood and cortisol concentrations in stress-vulnerable subjects under acute stress found it improved coping ability.

TL;DR: This first functional imaging study to investigate explicitly reward circuitry in OCD shows attenuated reward anticipation activity in the nucleus accumbens compared with healthy control subjects, and supports the conceptualization of OCD as a disorder of reward processing and behavioral addiction.

TL;DR: There is substantial evidence that patients with OCD may benefit from addition of antipsychotics to their ongoing SSRI treatment, suggesting that dopamine also might play a role in the pathophysiology of OCD.

TL;DR: These data provide evidence for reduced pain sensitivity in PTSD and the witnessed neural activation pattern is proposed to be related to altered pain processing in patients with PTSD.