Herman M. Kalckar

TL;DR: Galactosemia seems to furnish an example of a congenital human metabolic disease in which a specific enzyme is missing and several of the metabolic manifestations of the disease might readily be explained on the basis of this enzymatic defect.

TL;DR: Thiosemicarbazide exerts a type of inhibition on the enzyme which indicates the presence of a carbonyl group on the catalytic site of the protein, which could lead to the possibility of the dehydrogenase being one enzyme catalyzing both the oxidation steps involved in the conversion of uridine diphosphoglucose to uridinediph phosphoglucuronic acid.