H
Hesham K. Yosef
Researcher at Ruhr University Bochum
Publications - 19
Citations - 445
Hesham K. Yosef is an academic researcher from Ruhr University Bochum. The author has contributed to research in topics: Epidermal growth factor receptor & Medicine. The author has an hindex of 10, co-authored 15 publications receiving 328 citations.
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Journal ArticleDOI
Label-free imaging of drug distribution and metabolism in colon cancer cells by Raman microscopy
Samir F. El-Mashtoly,Dennis Petersen,Hesham K. Yosef,Axel Mosig,Anke Reinacher-Schick,Carsten Kötting,Klaus Gerwert +6 more
TL;DR: It is demonstrated that Raman microscopy will open avenues as a non-invasive and label-free technique to investigate pharmacokinetics at the highest possible resolution in living cells.
Journal ArticleDOI
Label-Free Raman Spectroscopic Imaging Monitors the Integral Physiologically Relevant Drug Responses in Cancer Cells.
Samir F. El-Mashtoly,Hesham K. Yosef,Dennis Petersen,Laven Mavarani,Abdelouahid Maghnouj,Stephan A. Hahn,Carsten Kötting,Klaus Gerwert +7 more
TL;DR: A noninvasive, label-free, in vitro vibrational spectroscopic test to determine the integral physiologically relevant drug response in cell lines is developed and opens a new field of patient-centered drug testing that could deliver superior patient therapies.
Journal ArticleDOI
Raman Microspectroscopic Evidence for the Metabolism of a Tyrosine Kinase Inhibitor, Neratinib, in Cancer Cells
Karim Aljakouch,Tatjana Lechtonen,Hesham K. Yosef,Mohamad K. Hammoud,Wissam Alsaidi,Carsten Kötting,Carolin Mügge,Robert Kourist,Samir F. El-Mashtoly,Klaus Gerwert +9 more
TL;DR: The intracellular spatial distribution and metabolism of neratinib in different cancer cells using label‐free Raman imaging is reported for the first time, suggesting that both EGFR and HER2 follow the classical endosome lysosomal pathway for degradation.
Journal ArticleDOI
Noninvasive Diagnosis of High-Grade Urothelial Carcinoma in Urine by Raman Spectral Imaging
Hesham K. Yosef,Sascha D. Krauß,Tatjana Lechtonen,Hendrik Jütte,Andrea Tannapfel,Heiko U. Käfferlein,Thomas Brüning,Florian Roghmann,Joachim Noldus,Axel Mosig,Samir F. El-Mashtoly,Klaus Gerwert +11 more
TL;DR: A novel noninvasive, label-free approach with high sensitivity for use with urine is presented, paving the way for "spectral" cytology of urine using Raman microspectroscopy.
Journal ArticleDOI
SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and Iron Metabolism
Romy Kronstein-Wiedemann,Marlena Stadtmüller,Sofia Traikov,Mandy Georgi,M. Teichert,Hesham K. Yosef,Jan Wallenborn,Andreas Karl,Karin Schütze,Michael Wagner,Ali El-Armouche,Torsten Tonn +11 more
TL;DR: In this article , the authors demonstrate that SARS-CoV-2 directly infects erythroid precursor cells, impairs hemoglobin homeostasis and aggravates COVID-19 disease.