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Samir F. El-Mashtoly
Researcher at Ruhr University Bochum
Publications - 47
Citations - 1625
Samir F. El-Mashtoly is an academic researcher from Ruhr University Bochum. The author has contributed to research in topics: Heme & Epidermal growth factor receptor. The author has an hindex of 18, co-authored 47 publications receiving 1109 citations. Previous affiliations of Samir F. El-Mashtoly include National Institutes of Natural Sciences, Japan & King Khalid University.
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Journal ArticleDOI
Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes.
Sarah H Shahmoradian,Sarah H Shahmoradian,Amanda J Lewis,Christel Genoud,Jürgen Hench,Tim Moors,Paula P Navarro,Daniel Castaño-Díez,Gabriel Schweighauser,Alexandra Graff-Meyer,Kenneth N. Goldie,Rosmarie Sütterlin,Evelien Huisman,Angela Ingrassia,Yvonne de Gier,Annemieke J.M. Rozemuller,Jing Wang,Anne De Paepe,Johannes Erny,Andreas Staempfli,Joerg Hoernschemeyer,Frederik Großerüschkamp,Daniel Niedieker,Samir F. El-Mashtoly,Marialuisa Quadri,Wilfred F. J. van IJcken,Vincenzo Bonifati,Klaus Gerwert,Bernd Bohrmann,Stephan Frank,Markus Britschgi,Henning Stahlberg,Wilma D.J. van de Berg,Matthias E. Lauer +33 more
TL;DR: Using three-dimensional correlative light and electron microscopy of Lewy bodies and Lewy neurites in postmortem brains of Parkinson’s disease patients, researchers show that the major constituents are membranes rather than proteinaceous filaments.
Journal ArticleDOI
Label-free imaging of drug distribution and metabolism in colon cancer cells by Raman microscopy
Samir F. El-Mashtoly,Dennis Petersen,Hesham K. Yosef,Axel Mosig,Anke Reinacher-Schick,Carsten Kötting,Klaus Gerwert +6 more
TL;DR: It is demonstrated that Raman microscopy will open avenues as a non-invasive and label-free technique to investigate pharmacokinetics at the highest possible resolution in living cells.
Journal ArticleDOI
Unifying photocycle model for light adaptation and temporal evolution of cation conductance in channelrhodopsin-2.
Jens Kuhne,Johannes Vierock,Stefan Alexander Tennigkeit,Max-Aylmer Dreier,Jonas Wietek,Dennis Petersen,Konstantin Gavriljuk,Samir F. El-Mashtoly,Peter Hegemann,Klaus Gerwert +9 more
TL;DR: Parallel anti- and syn-photocycles now explain inactivation and ion selectivity changes of ChR2 during continuous illumination, fostering the future rational design of optogenetic tools.
Journal ArticleDOI
Label-Free Raman Spectroscopic Imaging Monitors the Integral Physiologically Relevant Drug Responses in Cancer Cells.
Samir F. El-Mashtoly,Hesham K. Yosef,Dennis Petersen,Laven Mavarani,Abdelouahid Maghnouj,Stephan A. Hahn,Carsten Kötting,Klaus Gerwert +7 more
TL;DR: A noninvasive, label-free, in vitro vibrational spectroscopic test to determine the integral physiologically relevant drug response in cell lines is developed and opens a new field of patient-centered drug testing that could deliver superior patient therapies.
Journal ArticleDOI
Spectral histopathology of colon cancer tissue sections by Raman imaging with 532 nm excitation provides label free annotation of lymphocytes, erythrocytes and proliferating nuclei of cancer cells
Laven Mavarani,Dennis Petersen,Samir F. El-Mashtoly,Axel Mosig,Andrea Tannapfel,Carsten Kötting,Klaus Gerwert +6 more
TL;DR: It is found that this auto-fluorescence overlaps spatially with the fluorescence of antibodies against p53 used in routine immunohistochemistry in surgical pathology and allows new label free assignment of cancer cells to open new avenues for optical diagnosis by Raman spectroscopy and autofluorescence.