H
Hidemitsu Kitamura
Researcher at Hokkaido University
Publications - 73
Citations - 4358
Hidemitsu Kitamura is an academic researcher from Hokkaido University. The author has contributed to research in topics: Cytotoxic T cell & Antigen. The author has an hindex of 25, co-authored 67 publications receiving 3883 citations.
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Journal ArticleDOI
The Natural Killer T (NKT) Cell Ligand α-Galactosylceramide Demonstrates Its Immunopotentiating Effect by Inducing Interleukin (IL)-12 Production by Dendritic Cells and IL-12 Receptor Expression on NKT Cells
Hidemitsu Kitamura,Kenji Iwakabe,Takashi Yahata,Shin-Ichiro Nishimura,Akio Ohta,Yasushi Ohmi,Marimo Sato,Kazuyoshi Takeda,Ko Okumura,Luc Van Kaer,Tetsu Kawano,Masaru Taniguchi,Takashi Nishimura +12 more
TL;DR: Findings indicate an important role for DC-produced IL-12 in the activation of NKT cells by α-GalCer and suggest that N KT cells may be able to condition DCs for subsequent immune responses and suggest a novel approach for immunotherapy of cancer.
The natural killer T (NKT) cell ligand _-galactosylceramide′ demonstrates its immunopotentiating effect by inducing′ intreleukin (IL)-12 production by dendritic cells and IL-12′ receptor expression on NKT cells.
Hidemitsu Kitamura,Kenji Iwakabe,Takashi Yahata,Shin-Ichiro Nishimura,Akio Ohta,Yasushi Ohmi,Marimo Sato,Kazuyoshi Takeda,Kyoko Okumura,L. Van Kaer,Tetsu Kawano,Masaru Taniguchi,Takashi Nishimura +12 more
Abstract: The natural killer T (NKT) cell ligand α-galactosylceramide (α-GalCer) exhibits profound antitumor activities in vivo that resemble interleukin (IL)-12–mediated antitumor activities. Because of these similarities between the activities of α-GalCer and IL-12, we investigated the involvement of IL-12 in the activation of NKT cells by α-GalCer. We first established, using purified subsets of various lymphocyte populations, that α-GalCer selectively activates NKT cells for production of interferon (IFN)-γ. Production of IFN-γ by NKT cells in response to α-GalCer required IL-12 produced by dendritic cells (DCs) and direct contact between NKT cells and DCs through CD40/CD40 ligand interactions. Moreover, α-GalCer strongly induced the expression of IL-12 receptor on NKT cells from wild-type but not CD1−/− or Vα14−/− mice. This effect of α-GalCer required the production of IFN-γ by NKT cells and production of IL-12 by DCs. Finally, we showed that treatment of mice with suboptimal doses of α-GalCer together with suboptimal doses of IL-12 resulted in strongly enhanced natural killing activity and IFN-γ production. Collectively, these findings indicate an important role for DC-produced IL-12 in the activation of NKT cells by α-GalCer and suggest that NKT cells may be able to condition DCs for subsequent immune responses. Our results also suggest a novel approach for immunotherapy of cancer.
Journal ArticleDOI
IL-6 Regulates In Vivo Dendritic Cell Differentiation through STAT3 Activation
Sung Joo Park,Takayuki Nakagawa,Hidemitsu Kitamura,Toru Atsumi,Hokuto Kamon,Shinichiro Sawa,Daisuke Kamimura,Naoko Ueda,Yoichiro Iwakura,Katsuhiko Ishihara,Masaaki Murakami,Toshio Hirano +11 more
TL;DR: IL-6 is a potent regulator of DC differentiation in vivo, and IL-6-gp130-STAT3 signaling in DCs may represent a critical target for controlling T cell-mediated immune responses in vivo.
Journal ArticleDOI
Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function.
Hidemitsu Kitamura,Hideyuki Morikawa,Hokuto Kamon,Megumi Iguchi,Shintaro Hojyo,Toshiyuki Fukada,Susumu Yamashita,Tsuneyasu Kaisho,Shizuo Akira,Masaaki Murakami,Toshio Hirano +10 more
TL;DR: It is shown that stimulation with the Toll-like receptor 4 agonist lipopolysaccharide (LPS) altered the expression of zinc transporters in dendritic cells and thereby decreased intracellular free zinc, establishing a link between Toll- like receptor signaling and zinc homeostasis.
Journal ArticleDOI
Local radiation therapy inhibits tumor growth through the generation of tumor-specific CTL: its potentiation by combination with Th1 cell therapy.
Tsuguhide Takeshima,Kenji Chamoto,Daiko Wakita,Takayuki Ohkuri,Yuji Togashi,Hiroki Shirato,Hidemitsu Kitamura,Takashi Nishimura +7 more
TL;DR: It is concluded that the combination treatment of local radiation therapy and Th1 cell therapy is a rational strategy to augment antitumor activity mediated by tumor-specific CTL.