H
Hidetaka Akita
Researcher at Chiba University
Publications - 207
Citations - 10486
Hidetaka Akita is an academic researcher from Chiba University. The author has contributed to research in topics: Gene delivery & Transfection. The author has an hindex of 47, co-authored 190 publications receiving 9393 citations. Previous affiliations of Hidetaka Akita include Hokkaido University & National Institute of Advanced Industrial Science and Technology.
Papers
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Journal ArticleDOI
Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery
TL;DR: The different uptake pathways that are involved in nonviral gene delivery from a gene delivery point of view are reviewed and available knowledge concerning cellular entry and the intracellular trafficking of cationic lipid-DNA complexes (lipoplexes) and cationsic polymer- DNA complexes (polyplexes) is summarized.
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A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma.
TL;DR: The development and applications of MEND are described, and strategies for overcoming the PEG dilemma are discussed, based on the manipulation of intracellular trafficking of cellular uptake and endosomal release using functional devices such as specific ligands, cleavable PEG systems andendosomal fusogenic/disruptic peptides.
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Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid.
Hiroto Hatakeyama,Hidetaka Akita,Kentaro Kogure,Motoi Oishi,Yukio Nagasaki,Y Kihira,M Ueno,H Kobayashi,H Kikuchi,Hideyoshi Harashima +9 more
TL;DR: In vivo studies revealed that the PPD was potent in stabilizing MEND in the systemic circulation and facilitating tumor accumulation, and MEND modified with PPD is a promising device, which has the potential to make in vivo cancer gene therapy achievable.
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The polyethyleneglycol dilemma: advantage and disadvantage of PEGylation of liposomes for systemic genes and nucleic acids delivery to tumors.
TL;DR: The development and applications of MEND are described, various strategies for overcoming the PEG dilemma based on the manipulation of both pharmacokinetics and intracellular trafficking of cellular uptake and endosomal release are discussed and pH- sensitive liposomes using pH-sensitive lipids are described.
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The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus
Seiichi Sato,Kai Li,Takeshi Kameyama,Takaya Hayashi,Yuji Ishida,Shuko Murakami,Tsunamasa Watanabe,Sayuki Iijima,Yu Sakurai,Koichi Watashi,Susumu Tsutsumi,Yusuke Sato,Hidetaka Akita,Takaji Wakita,Charles M. Rice,Hideyoshi Harashima,Michinori Kohara,Yasuhito Tanaka,Akinori Takaoka +18 more
TL;DR: Type III but not type I interferons are predominantly induced in human primary hepatocytes in response to HBV infection, through retinoic acid-inducible gene-I (RIG-I)-mediated sensing of the 5'-ε region of HBV pregenomic RNA.